Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients.

Adult Biological Transport / drug effects Exenatide / metabolism Female Gelatin / pharmacology Humans Image Processing, Computer-Assisted Indium Radioisotopes / therapeutic use Insulinoma / diagnostic imaging Isotope Labeling Kidney / drug effects Male Single Photon Emission Computed Tomography Computed Tomography Succinates / pharmacology
dosimetry exendin-4 insulinoma kidney uptake radionuclide therapy

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
06 2019
Historique:
received: 06 09 2018
accepted: 26 10 2018
pubmed: 7 12 2018
medline: 31 3 2020
entrez: 4 12 2018
Statut: ppublish

Résumé

Being highly expressed in insulinomas, the glucagonlike peptide-1 receptor (GLP-1R) is a potential target for diagnosis, localization, and treatment with the radiolabeled GLP-1R agonist exendin. Tracer accumulation in the kidneys, however, hampers accurate diagnostic visualization of pancreatic tissue and prohibits the therapeutic application of radiolabeled exendin for β-cell-derived tumors. Therefore, we evaluated the ability of succinylated gelatin (Gelofusine) to reduce the renal accumulation of radiolabeled exendin in humans, and we performed dosimetric calculations to estimate the maximum absorbed insulinoma dose that could be achieved if exendin were to be used for peptide receptor radionuclide therapy.

Identifiants

DOI: 10.2967/jnumed.118.219980 PMID: 30504139
pubmed: 30504139
pii: jnumed.118.219980
doi: 10.2967/jnumed.118.219980
doi:

Substances chimiques

Indium Radioisotopes 0
Succinates 0
succinylated gelatin 39340-57-3
Gelatin 9000-70-8
Exenatide 9P1872D4OL
Indium-111 E9NGC49E0T

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

812-816

Informations de copyright

© 2019 by the Society of Nuclear Medicine and Molecular Imaging.

Auteurs

Mijke Buitinga (M)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Martin.Gotthardt@radboudumc.nl.

Tom Jansen (T)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Inge van der Kroon (I)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Wietske Woliner-van der Weg (W)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Marti Boss (M)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Marcel Janssen (M)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Erik Aarntzen (E)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Martin Béhé (M)

Center for Radiopharmaceutical Sciences, ETH-PSI-USZ, Paul Scherrer Institute, Villigen, Switzerland; and.

Damian Wild (D)

Division of Nuclear Medicine, University Hospital Basel, Basel, Switzerland.

Eric Visser (E)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Maarten Brom (M)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Martin Gotthardt (M)

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Métabolisme › Transport biologique › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Exénatide › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Gélatine › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes de l'indium › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Adénome langerhansien › Insulinome › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Techniques d'investigation › Marquage isotopique › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission monophotonique › Tomographie par émission monophotonique couplée à la tomodensitométrie › Succinylated Gelatin Improves the Theranostic...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Succinates › Succinylated Gelatin Improves the Theranostic...