Employment of fucosidases for the synthesis of fucosylated oligosaccharides with biological potential.
enzymatic synthesis
fucooligosaccharides
fucosidases
transfucosylation
Journal
Biotechnology and applied biochemistry
ISSN: 1470-8744
Titre abrégé: Biotechnol Appl Biochem
Pays: United States
ID NLM: 8609465
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
15
06
2018
revised:
24
10
2018
accepted:
15
11
2018
pubmed:
7
12
2018
medline:
18
4
2019
entrez:
4
12
2018
Statut:
ppublish
Résumé
Fucosylated oligosaccharides play important physiological roles in humans, including in the immune response, transduction of signals, early embryogenesis and development, growth regulation, apoptosis, pathogen adhesion, and so on. Efforts have been made to synthesize fucosylated oligosaccharides, as it is difficult to purify them from their natural sources, such as human milk, epithelial tissue, blood, and so on. Within the strategies for its in vitro synthesis, it is remarkable the employment of fucosidases, enzymes that normally cleave the fucosyl residue from the non-reducing end of fucosylated compounds, as these enzymes are also capable of synthesizing them by means of a transfucosylation reaction. This review summarizes the progress in the use of fucosidases for the synthesis of compounds that have potential for industrial and commercial applications.
Substances chimiques
Oligosaccharides
0
Fucose
28RYY2IV3F
alpha-L-Fucosidase
EC 3.2.1.51
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
172-191Informations de copyright
© 2018 International Union of Biochemistry and Molecular Biology, Inc.