Protective effects of alpha-ketoglutarate against aluminum toxicity in Drosophila melanogaster.

Aluminum / toxicity Animals Antioxidants / pharmacology Drosophila melanogaster / drug effects Ketoglutaric Acids / pharmacology Larva / drug effects Oxidative Stress / drug effects
Antioxidant Fecundity Mitochondrial dysfunction Oxidative stress Pupation Survival Triacylglycerides

Journal

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
ISSN: 1532-0456
Titre abrégé: Comp Biochem Physiol C Toxicol Pharmacol
Pays: United States
ID NLM: 100959500

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 17 10 2018
revised: 26 11 2018
accepted: 28 11 2018
pubmed: 7 12 2018
medline: 26 2 2019
entrez: 4 12 2018
Statut: ppublish

Résumé

In recent years, Drosophila melanogaster has emerged as a model for studies on aluminum toxicity. The current study aimed to disclose the mechanisms of aluminum toxicity in D. melanogaster at larval and adult stages and examined the potential protective effects of dietary alpha-ketoglutarate (AKG). Flies were reared on food containing 10 mM AlCl

Identifiants

DOI: 10.1016/j.cbpc.2018.11.020 PMID: 30508642
pubmed: 30508642
pii: S1532-0456(18)30214-X
doi: 10.1016/j.cbpc.2018.11.020
pii:
doi:

Substances chimiques

Antioxidants 0
Ketoglutaric Acids 0
Aluminum CPD4NFA903

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

41-53

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Maria M Bayliak (MM)

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76018, Ukraine. Electronic address: bayliak@ukr.net.

Maria P Lylyk (MP)

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76018, Ukraine.

Dmytro V Gospodaryov (DV)

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76018, Ukraine. Electronic address: dmytro.hospodarov@pu.if.ua.

Volodymyr O Kotsyubynsky (VO)

Department of Materials Science and Advanced Technologies, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76018, Ukraine.

Nataliia V Butenko (NV)

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76018, Ukraine.

Kenneth B Storey (KB)

Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada.

Volodymyr I Lushchak (VI)

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76018, Ukraine. Electronic address: lushchak@pu.if.ua.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Aluminium › Protective effects of alpha-ketoglutarate...
questionsmedicales.fr › Eucaryotes › Animaux › Protective effects of alpha-ketoglutarate...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Protective effects of alpha-ketoglutarate...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Protective effects of alpha-ketoglutarate...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Acides cétoglutariques › Protective effects of alpha-ketoglutarate...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Larve › Protective effects of alpha-ketoglutarate...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Protective effects of alpha-ketoglutarate...