Polysaccharide structure dictates mechanism of adaptive immune response to glycoconjugate vaccines.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
02 01 2019
Historique:
pubmed: 5 12 2018
medline: 19 3 2019
entrez: 5 12 2018
Statut: ppublish

Résumé

Glycoconjugate vaccines are among the most effective interventions for preventing several serious infectious diseases. Covalent linkage of the bacterial capsular polysaccharide to a carrier protein provides CD4

Identifiants

pubmed: 30510007
pii: 1816401115
doi: 10.1073/pnas.1816401115
pmc: PMC6320544
doi:

Substances chimiques

Antigens 0
Epitopes 0
Glycoconjugates 0
Meningococcal Vaccines 0
Polysaccharides, Bacterial 0
Vaccines, Conjugate 0
serogroup C meningococcal conjugate vaccine 0
N-Acetylneuraminic Acid GZP2782OP0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

193-198

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI089915
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109764
Pays : United States

Commentaires et corrections

Type : CommentIn

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

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Auteurs

Ximei Sun (X)

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115.

Giuseppe Stefanetti (G)

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Department of Chemistry, University of Milan, 20133 Milan, Italy.

Francesco Berti (F)

Technical R&D, GSK Vaccines, 53100 Siena, Italy.

Dennis L Kasper (DL)

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; dennis_kasper@hms.harvard.edu.

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Classifications MeSH