Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis.
Adult
Aged
Aged, 80 and over
Cells, Cultured
Dermatitis
/ immunology
Female
Fibroblasts
/ physiology
Humans
Inflammation
/ immunology
Lupus Erythematosus, Discoid
/ immunology
Male
Middle Aged
Scleroderma, Systemic
/ immunology
Skin
/ immunology
T-Lymphocytes
/ immunology
Thy-1 Antigens
/ metabolism
Vascular Cell Adhesion Molecule-1
/ metabolism
Young Adult
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
31
08
2018
accepted:
29
10
2018
pubmed:
5
12
2018
medline:
5
11
2019
entrez:
5
12
2018
Statut:
ppublish
Résumé
Perivascular accumulation of lymphocytes can be a prominent histopathologic feature of various human inflammatory skin diseases. Select examples include systemic sclerosis, spongiotic dermatitis, and cutaneous lupus. Although a large body of work has described various aspects of the endothelial and vascular smooth muscle layers in these diseases, the outer adventitial compartment is poorly explored. The goal of the current study was to characterize perivascular adventitial fibroblast states in inflammatory human skin diseases and relate these states to perivascular lymphocyte accumulation. In normal skin, adventitial fibroblasts are distinguished by CD90 expression, and dense perivascular lymphocytic infiltrates are uncommon. In systemic sclerosis, this compartment expands, but lymphocyte infiltrates remain sparse. In contrast, perivascular adventitial fibroblast expression of VCAM1 is upregulated in spongiotic dermatitis and lupus and is associated with a dense perivascular T cell infiltrate. VCAM1 expression marks transitioned fibroblasts that show some resemblance to the reticular stromal cells in secondary lymphoid organs. Expanded adventitial compartments with perivascular infiltrates similar to the human settings were not seen in the inflamed murine dermis. This species difference may hinder the dissection of aspects of perivascular adventitial pathology. The altered perivascular adventitial compartment and its associated reticular network form a niche for lymphocytes and appear to be fundamental in the development of an inflammatory pattern.
Identifiants
pubmed: 30510068
pii: jimmunol.1801209
doi: 10.4049/jimmunol.1801209
pmc: PMC6305793
mid: NIHMS1511651
doi:
Substances chimiques
Thy-1 Antigens
0
Vascular Cell Adhesion Molecule-1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-68Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR061271
Pays : United States
Organisme : NIAMS NIH HHS
ID : P50 AR060780
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007309
Pays : United States
Informations de copyright
Copyright © 2018 by The American Association of Immunologists, Inc.
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