Randomized controlled trial of individualized treatment summary and survivorship care plans for hematopoietic cell transplantation survivors.
Adolescent
Adult
Aged
Aged, 80 and over
Cancer Survivors
/ statistics & numerical data
Continuity of Patient Care
/ organization & administration
Female
Follow-Up Studies
Hematologic Diseases
/ rehabilitation
Hematopoietic Stem Cell Transplantation
/ methods
Humans
Male
Middle Aged
Patient Care Planning
/ standards
Patient Reported Outcome Measures
Patient-Centered Care
/ organization & administration
Precision Medicine
Prognosis
Quality of Life
Surveys and Questionnaires
Survival Rate
Survivorship
Young Adult
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
06
08
2018
accepted:
23
11
2018
pubmed:
6
12
2018
medline:
21
5
2020
entrez:
6
12
2018
Statut:
ppublish
Résumé
Survivorship Care Plans (SCPs) may facilitate long-term care for cancer survivors, but their effectiveness has not been established in hematopoietic cell transplantation recipients. We evaluated the impact of individualized SCPs on patient-reported outcomes among transplant survivors. Adult (≥18 years at transplant) survivors who were 1-5 years post transplantation, proficient in English, and without relapse or secondary cancers were eligible for this multicenter randomized trial. SCPs were developed based on risk-factors and treatment exposures using patient data routinely submitted by transplant centers to the Center for International Blood and Marrow Transplant Research and published guidelines for long-term follow up of transplant survivors. Phone surveys assessing patient-reported outcomes were conducted at baseline and at 6 months. The primary end point was confidence in survivorship information, and secondary end points included cancer and treatment distress, knowledge of transplant exposures, health care utilization, and health-related quality of life. Of 495 patients enrolled, 458 completed a baseline survey and were randomized (care plan=231, standard care=227); 200 (87%) and 199 (88%) completed the 6-month assessments, respectively. Patients' characteristics were similar in the two arms. Participants on the care plan arm reported significantly lower distress scores at 6 months and an increase in the Mental Component Summary quality of life score assessed by the Short Form 12 (SF-12) instrument. No effect was observed on the end point of confidence in survivorship information or other secondary outcomes. Provision of individualized SCPs generated using registry data was associated with reduced distress and improved mental domain of quality of life among 1-5 year hematopoietic cell transplantation survivors. Trial registered at
Identifiants
pubmed: 30514795
pii: haematol.2018.203919
doi: 10.3324/haematol.2018.203919
pmc: PMC6518896
doi:
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1084-1092Subventions
Organisme : Patient-Centered Outcomes Research Institute
ID : CD-12-11-4062
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215134
Pays : United States
Informations de copyright
Copyright© 2019 Ferrata Storti Foundation.
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