Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain.
Animals
Blood Glucose
/ drug effects
Diabetes Mellitus, Experimental
/ drug therapy
Diabetes Mellitus, Type 2
/ drug therapy
Fibroblast Growth Factor 1
/ therapeutic use
Glucokinase
/ genetics
Glucose Tolerance Test
Humans
Hypoglycemic Agents
/ therapeutic use
Insulin
/ metabolism
Insulin Resistance
Male
Rats
Rats, Zucker
Real-Time Polymerase Chain Reaction
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
03
05
2018
accepted:
29
10
2018
pubmed:
14
12
2018
medline:
27
8
2019
entrez:
8
12
2018
Statut:
ppublish
Résumé
We recently reported that in rodent models of type 2 diabetes (T2D), a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces remission of hyperglycemia that is sustained for weeks. To clarify the peripheral mechanisms underlying this effect, we used the Zucker diabetic fatty
Identifiants
pubmed: 30523024
pii: db18-0498
doi: 10.2337/db18-0498
pmc: PMC6385755
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Insulin
0
Fibroblast Growth Factor 1
104781-85-3
Glucokinase
EC 2.7.1.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Pagination
654-664Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007028
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK089056
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK083042
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101997
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK027619
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK114474
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK027619
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2018 by the American Diabetes Association.
Références
J Clin Invest. 2012 Jan;122(1):4-12
pubmed: 22214853
Metabolism. 2000 May;49(5):684-8
pubmed: 10831184
Adv Exp Med Biol. 2010;654:463-77
pubmed: 20217510
Metabolism. 1992 Jan;41(1):22-7
pubmed: 1538640
Cell Metab. 2017 Nov 7;26(5):709-718.e3
pubmed: 28988823
J Clin Invest. 2013 Nov;123(11):4799-808
pubmed: 24084738
J Anat. 2010 Nov;217(5):624-30
pubmed: 20807269
Nat Rev Neurosci. 2013 Jan;14(1):24-37
pubmed: 23232606
FASEB J. 2002 Apr;16(6):509-18
pubmed: 11919153
Nat Commun. 2015 Apr 28;6:6980
pubmed: 25916467
Diabetes. 2013 Feb;62(2):392-400
pubmed: 23028137
J Clin Invest. 1973 Jan;52(1):210-4
pubmed: 4682384
Science. 2011 Mar 25;331(6024):1621-4
pubmed: 21436455
Diabetes. 2017 Apr;66(4):823-834
pubmed: 28115396
Gastroenterology. 1996 Mar;110(3):885-93
pubmed: 8608899
Diabetes Care. 2012 May;35(5):1015-20
pubmed: 22456868
Diabetes Obes Metab. 2014 Sep;16 Suppl 1:33-40
pubmed: 25200294
Diabetes. 2015 Jul;64(7):2376-87
pubmed: 25633417
Diabetologia. 2000 Apr;43(4):393-410
pubmed: 10819232
Sci Rep. 2017 Jul 17;7(1):5578
pubmed: 28717164
Diabetes. 1998 Mar;47(3):358-64
pubmed: 9519740
Nature. 2014 Sep 18;513(7518):436-9
pubmed: 25043058
Mol Metab. 2017 Jul 08;6(9):943-957
pubmed: 28951820
Anat Rec A Discov Mol Cell Evol Biol. 2004 Sep;280(1):808-20
pubmed: 15382020
Mol Metab. 2013 Oct 23;3(1):19-28
pubmed: 24567901
Brain Res. 1984 Jun 11;303(1):147-52
pubmed: 6733521
Diabetes. 2005 May;54(5):1324-30
pubmed: 15855316
Diabetes. 2012 Feb;61(2):321-8
pubmed: 22210318
Methods Mol Biol. 2012;933:103-23
pubmed: 22893404
Physiol Rev. 2011 Apr;91(2):389-411
pubmed: 21527729
Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1105-14
pubmed: 19706786
Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1730-5
pubmed: 17895283
Nat Med. 2016 Jul;22(7):800-6
pubmed: 27213816
Endocrinology. 2004 Jun;145(6):2594-603
pubmed: 14976145
Mol Metab. 2015 Jun 04;4(8):561-8
pubmed: 26266088
Diabetes Care. 1996 Sep;19(9):1018-30
pubmed: 8875104
Nature. 2013 Nov 7;503(7474):59-66
pubmed: 24201279
Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E9-E16
pubmed: 16105863
Adv Nutr. 2012 May 01;3(3):286-94
pubmed: 22585902
Endocrinology. 2013 Jan;154(1):9-15
pubmed: 23183168
J Clin Invest. 2005 Jun;115(6):1627-35
pubmed: 15902306
Diabetes. 2010 Jul;59(7):1817-24
pubmed: 20357365
Diabetes. 2009 Jan;58(1):78-86
pubmed: 18952838
Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23
pubmed: 15138155
Diabetes. 2016 Sep;65(9):2711-23
pubmed: 27207534
Endocrinology. 2011 Feb;152(2):394-404
pubmed: 21159853