Glioblastoma in a patient with tuberous sclerosis.

Brain Neoplasms / etiology Glioblastoma / etiology Humans Male Middle Aged Tuberous Sclerosis / complications
Brain tumors Glioblastoma TSC1/2 mutation Tuberous sclerosis

Journal

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
ISSN: 1532-2653
Titre abrégé: J Clin Neurosci
Pays: Scotland
ID NLM: 9433352

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 08 09 2018
accepted: 14 10 2018
pubmed: 12 12 2018
medline: 28 2 2019
entrez: 12 12 2018
Statut: ppublish

Résumé

Tuberous sclerosis complex (TSC) is a multisystem, autosomal dominant disorder with a wide clinical spectrum. The most common brain tumor associated with TSC is the low grade subependymal giant cell astrocytoma. Reports of high grade primary brain tumors in patients with TSC are rare. TSC1/2 mutation has been identified in glioblastoma (GBM) even though it probably does not increase the overall risk for GBM in patients with TSC. We present a 58-year-old patient with known TSC, admitted for new neurological symptoms, diagnosed with a large heterogeneous tumor involving most of the corpus callosum. Stereotactic needle brain biopsy confirmed the diagnosis to be GBM. Five previously reported similar cases are reviewed, reflecting diversity in clinical and radiological findings and indicating that a high index of clinical suspicion must be maintained in patients with TSC.

Identifiants

DOI: 10.1016/j.jocn.2018.10.083 PMID: 30528355
pubmed: 30528355
pii: S0967-5868(18)31552-2
doi: 10.1016/j.jocn.2018.10.083
pii:
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

153-155

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Amit Azriel (A)

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: azriela@post.bgu.ac.il.

Andrew Gogos (A)

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia.

TeWhiti Rogers (T)

Department of Pathology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.

Samuel Moscovici (S)

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia.

Patrick Lo (P)

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia.

Katharine Drummond (K)

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia.

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Glioblastoma in a patient with tuberous sclerosis.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Glioblastoma in a patient with tuberous sclerosis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Glioblastoma in a patient with tuberous sclerosis.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Glioblastoma in a patient with tuberous sclerosis.
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Syndromes néoplasiques héréditaires › Complexe de la sclérose tubéreuse › Glioblastoma in a patient with tuberous sclerosis.