Moxifloxacin as an inducer of apoptosis in melanoma cells: A study at the cellular and molecular level.

Anti-Bacterial Agents / pharmacology Antineoplastic Agents / pharmacology Apoptosis / drug effects Cell Line, Tumor Cell Survival / drug effects Humans Melanoma / drug therapy Moxifloxacin / pharmacology
Apoptosis DNA fragmentation GSH depletion Melanoma Moxifloxacin

Journal

Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 30 07 2018
revised: 23 10 2018
accepted: 03 12 2018
pubmed: 12 12 2018
medline: 15 1 2019
entrez: 12 12 2018
Statut: ppublish

Résumé

Fluoroquinolones were shown to be cytotoxic towards various cancer cell lines, thus representing a potentially important source of new anticancer agents. The aim of the present study was to examine the effect of moxifloxacin on cell viability, redox balance and apoptosis in both amelanotic - C32 and melanotic - COLO829 melanoma cells. Herein, we found that moxifloxacin decreases the viability of C32 and COLO829 cells in concentration- and time-dependent manner. The EC

Identifiants

DOI: 10.1016/j.tiv.2018.12.002 PMID: 30528372
pubmed: 30528372
pii: S0887-2333(18)30407-7
doi: 10.1016/j.tiv.2018.12.002
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antineoplastic Agents 0
Moxifloxacin U188XYD42P

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

75-92

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Artur Beberok (A)

Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Pharmaceutical Chemistry, Jagiellońska 4, 41-200 Sosnowiec, Poland. Electronic address: abeberok@sum.edu.pl.

Zuzanna Rzepka (Z)

Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Pharmaceutical Chemistry, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Michalina Respondek (M)

Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Pharmaceutical Chemistry, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Jakub Rok (J)

Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Pharmaceutical Chemistry, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Michał Stradowski (M)

Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Pharmaceutical Chemistry, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Dorota Wrześniok (D)

Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Pharmaceutical Chemistry, Jagiellońska 4, 41-200 Sosnowiec, Poland.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Moxifloxacin as an inducer of apoptosis in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Moxifloxacin as an inducer of apoptosis in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Moxifloxacin as an inducer of apoptosis in...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Moxifloxacin as an inducer of apoptosis in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Moxifloxacin as an inducer of apoptosis in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Moxifloxacin as an inducer of apoptosis in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Moxifloxacin as an inducer of apoptosis in...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Moxifloxacine › Moxifloxacin as an inducer of apoptosis in...