Jakub Rok

Affiliations

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Silesia, Jagiellońska 4, PL 41-200, Sosnowiec, Poland. Electronic address: jrok@sum.edu.pl.

Publications (37)

Chlortetracycline and melanin biopolymer - The risk of accumulation and implications for phototoxicity: An in vitro study on normal human melanocytes.

Chemico-biological interactions

Avec: Jakub Rok , Zuzanna Rzepka , Michalina Respondek , Artur Beberok , Dorota Wrześniok

Kanamycin induces free radicals formation in melanocytes: An important factor for aminoglycosides ototoxicity.

Journal of cellular biochemistry

Avec: Dorota Wrześniok , Jakub Rok , Artur Beberok , Zuzanna Rzepka , Michalina Respondek , Barbara Pilawa , Magdalena Zdybel , Marcin Delijewski , Ewa Buszman

PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study.

Cells

Avec: Piotr Kupczyk , Aleksandra Simiczyjew , Jakub Marczuk , Ewelina Dratkiewicz , Artur Beberok , Jakub Rok , Malgorzata Pieniazek , Przemyslaw Biecek , Dmitry Nevozhay , Bartosz Slowikowski , Grzegorz Chodaczek , Dorota Wrzesniok , Dorota Nowak , Piotr Donizy

Drug-Induced Photosensitivity-From Light and Chemistry to Biological Reactions and Clinical Symptoms.

Pharmaceuticals (Basel, Switzerland)

Avec: Justyna Kowalska , Jakub Rok , Zuzanna Rzepka , Dorota Wrześniok

Molecular and Biochemical Basis of Minocycline-Induced Hyperpigmentation-The Study on Normal Human Melanocytes Exposed to UVA and UVB Radiation.

International journal of molecular sciences

Avec: Jakub Rok , Zuzanna Rzepka , Justyna Kowalska , Klaudia Banach , Artur Beberok , Dorota Wrześniok

Astrogliosis in an Experimental Model of Hypovitaminosis B12: A Cellular Basis of Neurological Disorders due to Cobalamin Deficiency.

Cells

Avec: Zuzanna Rzepka , Jakub Rok , Justyna Kowalska , Klaudia Banach , Justyna Magdalena Hermanowicz , Artur Beberok , Beata Sieklucka , Dorota Gryko , Dorota Wrześniok

Cytotoxic and proapoptotic effect of doxycycline - An in vitro study on the human skin melanoma cells.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Jakub Rok , Marta Karkoszka , Zuzanna Rzepka , Michalina Respondek , Klaudia Banach , Artur Beberok , Dorota Wrześniok

The Anticancer Potential of Doxycycline and Minocycline-A Comparative Study on Amelanotic Melanoma Cell Lines.

International journal of molecular sciences

Avec: Jakub Rok , Zuzanna Rzepka , Justyna Kowalska , Klaudia Banach , Artur Beberok , Dorota Wrześniok

Chemosensitization of U-87 MG Glioblastoma Cells by Neobavaisoflavone towards Doxorubicin and Etoposide.

International journal of molecular sciences

Avec: Mateusz Maszczyk , Klaudia Banach , Marta Karkoszka , Zuzanna Rzepka , Jakub Rok , Artur Beberok , Dorota Wrześniok

Melanin Biopolymers in Pharmacology and Medicine-Skin Pigmentation Disorders, Implications for Drug Action, Adverse Effects and Therapy.

Pharmaceuticals (Basel, Switzerland)

Avec: Marta Karkoszka , Jakub Rok , Dorota Wrześniok

Streptomycin generates oxidative stress in melanin-producing cells: In vitro study with EPR spectroscopy evidence.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Zuzanna Rzepka , Jakub Rok , Magdalena Zdybel , Barbara Pilawa , Artur Beberok , Dorota Wrześniok

Moxifloxacin as an inducer of apoptosis in melanoma cells: A study at the cellular and molecular level.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Artur Beberok , Zuzanna Rzepka , Michalina Respondek , Jakub Rok , Michał Stradowski , Dorota Wrześniok

Molecular and Biochemical Basis of Fluoroquinolones-Induced Phototoxicity-The Study of Antioxidant System in Human Melanocytes Exposed to UV-A Radiation.

International journal of molecular sciences

Avec: Justyna Kowalska , Klaudia Banach , Jakub Rok , Artur Beberok , Zuzanna Rzepka , Dorota Wrześniok

Minocycline Impact on Redox Homeostasis of Normal Human Melanocytes HEMn-LP Exposed to UVA Radiation and Hydrogen Peroxide.

International journal of molecular sciences

Avec: Jakub Rok , Zuzanna Rzepka , Mateusz Maszczyk , Artur Beberok , Dorota Wrześniok

Cellular and Molecular Aspects of Anti-Melanoma Effect of Minocycline-A Study of Cytotoxicity and Apoptosis on Human Melanotic Melanoma Cells.

International journal of molecular sciences

Avec: Jakub Rok , Zuzanna Rzepka , Artur Beberok , Justyna Pawlik , Dorota Wrześniok

The Assessment of Anti-Melanoma Potential of Tigecycline-Cellular and Molecular Studies of Cell Proliferation, Apoptosis and Autophagy on Amelanotic and Melanotic Melanoma Cells.

Cells

Avec: Jakub Rok , Justyna Kowalska , Zuzanna Rzepka , Dominika Stencel , Anna Skorek , Klaudia Banach , Dorota Wrześniok

Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes.

Pathology oncology research : POR

Avec: Michalina Respondek , Artur Beberok , Zuzanna Rzepka , Jakub Rok , Dorota Wrześniok

Cobalamin Deficiency: Effect on Homeostasis of Cultured Human Astrocytes.

Cells

Avec: Zuzanna Rzepka , Jakub Rok , Michalina Respondek , Justyna Pawlik , Artur Beberok , Dorota Gryko , Dorota Wrześniok

MIM1 induces COLO829 melanoma cell death through mitochondrial membrane breakdown, GSH depletion, and DNA damage.

Fundamental & clinical pharmacology

Avec: Michalina Respondek , Artur Beberok , Zuzanna Rzepka , Jakub Rok , Dorota Wrześniok

Ketoprofen Combined with UVA Irradiation Exerts Higher Selectivity in the Mode of Action against Melanotic Melanoma Cells than against Normal Human Melanocytes.

International journal of molecular sciences

Avec: Klaudia Banach , Justyna Kowalska , Zuzanna Rzepka , Artur Beberok , Jakub Rok , Dorota Wrześniok

The Biochemical and Molecular Analysis of Changes in Melanogenesis Induced by UVA-Activated Fluoroquinolones-In Vitro Study on Human Normal Melanocytes.

Cells

Avec: Justyna Kowalska , Klaudia Banach , Artur Beberok , Jakub Rok , Zuzanna Rzepka , Dorota Wrześniok

UVA Radiation Enhances Lomefloxacin-Mediated Cytotoxic, Growth-Inhibitory and Pro-Apoptotic Effect in Human Melanoma Cells through Excessive Reactive Oxygen Species Generation.

International journal of molecular sciences

Avec: Artur Beberok , Zuzanna Rzepka , Jakub Rok , Klaudia Banach , Dorota Wrześniok

Cobalamin Deficiency May Induce Astrosenescence-An In Vitro Study.

Cells

Avec: Zuzanna Rzepka , Jakub Rok , Justyna Kowalska , Klaudia Banach , Dorota Wrześniok

Response of Human Glioblastoma Cells to Vitamin B12 Deficiency: A Study Using the Non-Toxic Cobalamin Antagonist.

Biology

Avec: Zuzanna Rzepka , Jakub Rok , Mateusz Maszczyk , Artur Beberok , Justyna Magdalena Hermanowicz , Dariusz Pawlak , Dorota Gryko , Dorota Wrześniok

The role of UVA radiation in ketoprofen-mediated BRAF-mutant amelanotic melanoma cells death - A study at the cellular and molecular level.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Klaudia Banach , Justyna Kowalska , Zuzanna Rzepka , Artur Beberok , Jakub Rok , Dorota Wrześniok

The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Artur Beberok , Jakub Rok , Zuzanna Rzepka , Krzysztof Marciniec , Stanisław Boryczka , Dorota Wrześniok

Mechanism of Anticancer Action of Novel Imidazole Platinum(II) Complex Conjugated with G2 PAMAM-OH Dendrimer in Breast Cancer Cells.

International journal of molecular sciences

Avec: Robert Czarnomysy , Anna Muszyńska , Jakub Rok , Zuzanna Rzepka , Krzysztof Bielawski

Neobavaisoflavone May Modulate the Activity of Topoisomerase Inhibitors towards U-87 MG Cells: An In Vitro Study.

Molecules (Basel, Switzerland)

Avec: Mateusz Maszczyk , Zuzanna Rzepka , Jakub Rok , Artur Beberok , Dorota Wrześniok

Changes in the Oxidation-Reduction State of Human Dermal Fibroblasts as an Effect of Lomefloxacin Phototoxic Action.

Cells

Avec: Justyna Kowalska , Klaudia Banach , Zuzanna Rzepka , Jakub Rok , Marta Karkoszka , Dorota Wrześniok

The Assessment of Meloxicam Phototoxicity in Human Normal Skin Cells: In Vitro Studies on Dermal Fibroblasts and Epidermal Melanocytes.

Molecules (Basel, Switzerland)

Avec: Marta Karkoszka , Jakub Rok , Klaudia Banach , Justyna Kowalska , Zuzanna Rzepka , Dorota Wrześniok

Interaction between moxifloxacin and Mcl-1 and MITF proteins: the effect on growth inhibition and apoptosis in MDA-MB-231 human triple-negative breast cancer cells.

Pharmacological reports : PR

Avec: Artur Beberok , Jakub Rok , Zuzanna Rzepka , Krzysztof Marciniec , Stanisław Boryczka , Dorota Wrześniok

The Assessment of the Phototoxic Action of Chlortetracycline and Doxycycline as a Potential Treatment of Melanotic Melanoma-Biochemical and Molecular Studies on COLO 829 and G-361 Cell Lines.

International journal of molecular sciences

Avec: Jakub Rok , Zuzanna Rzepka , Klaudia Banach , Justyna Kowalska , Dorota Wrześniok

Evaluation of Possible Neobavaisoflavone Chemosensitizing Properties towards Doxorubicin and Etoposide in SW1783 Anaplastic Astrocytoma Cells.

Cells

Avec: Mateusz Maszczyk , Klaudia Banach , Jakub Rok , Zuzanna Rzepka , Artur Beberok , Dorota Wrześniok

The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells.

Pharmacological reports : PR

Avec: Maciej Miliński , Monika Staś , Jakub Rok , Artur Beberok , Dorota Wrześniok

Phototoxic Reactions Inducted by Hydrochlorothiazide and Furosemide in Normal Skin Cells-In Vitro Studies on Melanocytes and Fibroblasts.

International journal of molecular sciences

Avec: Marta Karkoszka , Jakub Rok , Zuzanna Rzepka , Klaudia Banach , Justyna Kowalska , Dorota Wrześniok

Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells - Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Marta Karkoszka , Jakub Rok , Justyna Kowalska , Zuzanna Rzepka , Klaudia Banach , Dorota Wrześniok

The assessment of the phototoxic potential of drugs forming complexes with melanin - screening in vitro studies using normal skin cells with varying pigmentation irradiated by a sunlight simulator.

Chemico-biological interactions

Avec: Jakub Rok , Justyna Kowalska , Zuzanna Rzepka , Klaudia Banach , Dorota Wrześniok

Réseau de co-auteurs

Dorota Wrześniok 35 collaborations

Zuzanna Rzepka 34 collaborations

Artur Beberok 26 collaborations

Klaudia Banach 19 collaborations

Justyna Kowalska 16 collaborations

Michalina Respondek 7 collaborations

Marta Karkoszka 7 collaborations

Mateusz Maszczyk 5 collaborations

Dorota Gryko 3 collaborations

Barbara Pilawa 2 collaborations

Magdalena Zdybel 2 collaborations

Justyna Magdalena Hermanowicz 2 collaborations

Justyna Pawlik 2 collaborations

Krzysztof Marciniec 2 collaborations

Stanisław Boryczka 2 collaborations

Marcin Delijewski 1 collaboration

Ewa Buszman 1 collaboration

Piotr Kupczyk 1 collaboration

Aleksandra Simiczyjew 1 collaboration

Jakub Marczuk 1 collaboration

Ewelina Dratkiewicz 1 collaboration

Malgorzata Pieniazek 1 collaboration

Przemyslaw Biecek 1 collaboration

Dmitry Nevozhay 1 collaboration

Bartosz Slowikowski 1 collaboration

Grzegorz Chodaczek 1 collaboration

Dorota Wrzesniok 1 collaboration

Dorota Nowak 1 collaboration

Piotr Donizy 1 collaboration

Beata Sieklucka 1 collaboration

Michał Stradowski 1 collaboration

Dominika Stencel 1 collaboration

Anna Skorek 1 collaboration

Dariusz Pawlak 1 collaboration

Robert Czarnomysy 1 collaboration

Anna Muszyńska 1 collaboration

Krzysztof Bielawski 1 collaboration

Maciej Miliński 1 collaboration

Monika Staś 1 collaboration