Molecular and Biochemical Basis of Fluoroquinolones-Induced Phototoxicity-The Study of Antioxidant System in Human Melanocytes Exposed to UV-A Radiation.
Anti-Bacterial Agents
/ pharmacology
Antioxidants
/ metabolism
Catalase
/ metabolism
Fluoroquinolones
/ pharmacology
Gene Expression Regulation, Enzymologic
/ drug effects
Glutathione Peroxidase
/ metabolism
Humans
Melanins
/ metabolism
Melanocytes
/ metabolism
Moxifloxacin
/ pharmacology
Oxidative Stress
Skin
/ drug effects
Superoxide Dismutase
/ metabolism
Ultraviolet Rays
/ adverse effects
catalase
glutathione peroxidase
lomefloxacin
moxifloxacin
phototoxicity
superoxide dismutase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Dec 2020
19 Dec 2020
Historique:
received:
25
11
2020
revised:
10
12
2020
accepted:
16
12
2020
entrez:
23
12
2020
pubmed:
24
12
2020
medline:
2
4
2021
Statut:
epublish
Résumé
Phototoxicity of fluoroquinolones is connected with oxidative stress induction. Lomefloxacin (8-halogenated derivative) is considered the most phototoxic fluoroquinolone and moxifloxacin (8-methoxy derivative) the least. Melanin pigment may protect cells from oxidative damage. On the other hand, fluoroquinolone-melanin binding may lead to accumulation of drugs and increase their toxicity to skin. The study aimed to examine the antioxidant defense system status in normal melanocytes treated with lomefloxacin and moxifloxacin and exposed to UV-A radiation. The obtained results demonstrated that UV-A radiation enhanced only the lomefloxacin-induced cytotoxic effect in tested cells. It was found that fluoroquinolones alone and with UV-A radiation decreased superoxide dismutase (SOD) activity and
Identifiants
pubmed: 33352719
pii: ijms21249714
doi: 10.3390/ijms21249714
pmc: PMC7765951
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antioxidants
0
Fluoroquinolones
0
Melanins
0
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
lomefloxacin
L6BR2WJD8V
Moxifloxacin
U188XYD42P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical University of Silesia
ID : KNW-1-037/K/9/O
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