Cobalamin Deficiency May Induce Astrosenescence-An In Vitro Study.
astrosenescence
cellular senescence
cobalamin deficiency
vitamin B12
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 10 2022
28 10 2022
Historique:
received:
15
09
2022
revised:
19
10
2022
accepted:
26
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Cobalamin (vitamin B12) deficiency is one of the major factors causing degenerative changes in the nervous system and, thus, various neurological and psychiatric symptoms. The underlying cellular mechanism of this phenomenon is not yet fully understood. An accumulation of senescent astrocytes has been shown to contribute to a wide range of pathologies of the nervous system, including neurodegenerative disorders. This study aimed to investigate whether cobalamin deficiency triggers astrosenescence. After inducing cobalamin deficiency in normal human astrocytes in vitro, we examined biomarkers of cellular senescence: SA-β-gal, p16
Identifiants
pubmed: 36359805
pii: cells11213408
doi: 10.3390/cells11213408
pmc: PMC9655094
pii:
doi:
Substances chimiques
Vitamin B 12
P6YC3EG204
Cyclin-Dependent Kinase Inhibitor p16
0
Cyclin-Dependent Kinase Inhibitor p21
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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