Cobalamin Deficiency: Effect on Homeostasis of Cultured Human Astrocytes.
astrocytes
cobalamin
neurological disorders
vitamin B12 deficiency
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 11 2019
24 11 2019
Historique:
received:
20
10
2019
revised:
18
11
2019
accepted:
21
11
2019
entrez:
28
11
2019
pubmed:
28
11
2019
medline:
10
9
2020
Statut:
epublish
Résumé
Cobalamin deficiency is an important health problem. The major non-hematological symptoms of hypocobalaminemia are nervous system disorders, but the molecular and cellular mechanisms underlying this phenomenon have not yet been fully explained. Increasing scientific evidence is stressing the pivotal role of astrocyte dysfunction in the pathogenesis of a wide range of neurological disorders. In light of the above, the aim of this study was to develop an in vitro model of cobalamin deficiency by optimizing the conditions of astrocyte culture in the presence of vitamin B
Identifiants
pubmed: 31771278
pii: cells8121505
doi: 10.3390/cells8121505
pmc: PMC6952958
pii:
doi:
Substances chimiques
Catalase
EC 1.11.1.6
Caspases
EC 3.4.22.-
Vitamin B 12
P6YC3EG204
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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