Molecular and Biochemical Basis of Minocycline-Induced Hyperpigmentation-The Study on Normal Human Melanocytes Exposed to UVA and UVB Radiation.
MITF
UV radiation
melanin
melanocyte
minocycline
tyrosinase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Apr 2021
04 Apr 2021
Historique:
received:
26
02
2021
revised:
01
04
2021
accepted:
01
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
15
5
2021
Statut:
epublish
Résumé
Minocycline is a drug which induces skin hyperpigmentation. Its frequency reaches up to 50% of treated patients. The adverse effect diminishes the great therapeutic potential of minocycline, including antibacterial, neuroprotective, anti-inflammatory and anti-cancer actions. It is supposed that an elevated melanin level and drug accumulation in melanin-containing cells are related to skin hyperpigmentation. This study aimed to evaluate molecular and biochemical mechanism of minocycline-induced hyperpigmentation in human normal melanocytes, as well as the contribution of UV radiation to this side effect. The experiments involved the evaluation of cyto- and phototoxic potential of the drug using cell imaging with light and confocal microscopes as well as biochemical and molecular analysis of melanogenesis. We showed that minocycline induced melanin synthesis in epidermal melanocytes. The action was intensified by UV irradiation, especially with the UVB spectrum. Minocycline stimulated the expression of microphthalmia-associated transcription factor (
Identifiants
pubmed: 33916535
pii: ijms22073755
doi: 10.3390/ijms22073755
pmc: PMC8038496
pii:
doi:
Substances chimiques
MITF protein, human
0
Microphthalmia-Associated Transcription Factor
0
PMEL protein, human
0
gp100 Melanoma Antigen
0
Monophenol Monooxygenase
EC 1.14.18.1
Minocycline
FYY3R43WGO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Śląski Uniwersytet Medyczny
ID : PCN-2-043/N/0/F, PCN-1-097/K/0/F
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