Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia.
Animals
Caenorhabditis elegans
/ genetics
Caenorhabditis elegans Proteins
/ genetics
Calcium-Binding Proteins
/ genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental
Hypoxia
/ genetics
Longevity
/ genetics
Neuropeptides
/ genetics
Oxygen
/ metabolism
Proprotein Convertase 2
/ genetics
Receptors, G-Protein-Coupled
/ genetics
Signal Transduction
Anoxia
C. elegans
Neuropeptides
egl-3
nlp-40
unc-31
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
15
10
2018
revised:
05
12
2018
accepted:
05
12
2018
pubmed:
12
12
2018
medline:
22
1
2020
entrez:
12
12
2018
Statut:
ppublish
Résumé
Inadequate delivery of oxygen to organisms during development can lead to cell dysfunction/death and life-long disabilities. Although the susceptibility of developing cells to low oxygen conditions changes with maturation, the cellular and molecular pathways that govern responses to low oxygen are incompletely understood. Here we show that developing Caenorhabditis elegans are substantially more sensitive to anoxia than adult animals and that this sensitivity is controlled by nervous system generated hormones (e.g., neuropeptides). A screen of neuropeptide genes identified and validated nlp-40 and its receptor aex-2 as a key regulator of anoxic survival in developing worms. The survival-promoting action of impaired neuropeptide signaling does not rely on five known stress resistance pathways and is specific to anoxic insult. Together, these data highlight a novel cell non-autonomous pathway that regulates the susceptibility of developing organisms to anoxia.
Identifiants
pubmed: 30529384
pii: S0891-5849(18)31724-6
doi: 10.1016/j.freeradbiomed.2018.12.006
pii:
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Calcium-Binding Proteins
0
NLP-40 protein, C elegans
0
Neuropeptides
0
Receptors, G-Protein-Coupled
0
UNC-31 protein, C elegans
0
aex-2 protein, C elegans
0
EGL-3 proprotein convertase, C elegans
EC 3.4.21.94
Proprotein Convertase 2
EC 3.4.21.94
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-208Subventions
Organisme : NINDS NIH HHS
ID : R01 NS096746
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS124802
Pays : United States
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.