Freeze/thaw of IGG solutions.

Antibodies, Monoclonal / chemistry Chemistry, Pharmaceutical Chromatography, Gel / methods Circular Dichroism / methods Cryoprotective Agents / chemistry Crystallization Drug Storage Excipients / chemistry Freezing Hydrogen-Ion Concentration Immunoglobulin G / chemistry Mannitol / chemistry Protein Stability Trehalose / chemistry
Crystallization Freeze/thaw Monoclonal antibody Stability pH

Journal

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778

Informations de publication

Date de publication:
Jan 2019
Historique:
received: 06 09 2018
revised: 02 12 2018
accepted: 03 12 2018
pubmed: 12 12 2018
medline: 23 4 2019
entrez: 12 12 2018
Statut: ppublish

Résumé

In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG

Identifiants

DOI: 10.1016/j.ejpb.2018.12.001 PMID: 30529434
pubmed: 30529434
pii: S0939-6411(18)31113-5
doi: 10.1016/j.ejpb.2018.12.001
pii:
doi:

Substances chimiques

Antibodies, Monoclonal 0
Cryoprotective Agents 0
Excipients 0
Immunoglobulin G 0
Mannitol 3OWL53L36A
Trehalose B8WCK70T7I

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

185-189

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Jacqueline Horn (J)

Department of Pharmacy-Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

Sampeeti Jena (S)

Biostabilization Laboratory, Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.

Alptekin Aksan (A)

Biostabilization Laboratory, Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.

Wolfgang Friess (W)

Department of Pharmacy-Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address: wolfgang.friess@lrz.uni-muenchen.de.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie pharmaceutique › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie sur gel › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Dichroïsme circulaire › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Cryoprotecteurs › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Phénomènes chimiques › Cristallisation › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Techniques d'investigation › Stockage de médicament › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Excipients › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Phénomènes chimiques › Transition de phase › Congélation › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Glucides › Polyols › Mannitol › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Freeze/thaw of IGG solutions.
questionsmedicales.fr › Glucides › Sucres › Diholoside › Tréhalose › Freeze/thaw of IGG solutions.