Cardiotoxicity of Consolida rugulosa, a poisonous weed in Western China.
Cardiac toxicity
Consolida rugulosa
Norditerpene alkaloids
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
15 Apr 2019
15 Apr 2019
Historique:
received:
30
07
2018
revised:
03
11
2018
accepted:
23
11
2018
pubmed:
12
12
2018
medline:
21
3
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Poisonous weeds are a global problem since they not only hinder local economic development, but also cause ecological harm. Consolida rugulosa (family Ranunculaceae) is a weed that is widespread in Northwestern China and causes severe poisoning when ingested by livestock. In the present study, we purified the toxins in this plant and investigated their mechanism of action. Five natural diterpene alkaloids (compounds 1-5)-including two new compounds (1 and 2)-were isolated, and five semi-synthetic derivatives (6-10) were synthesised based on 4 or 5 for structure-activity analysis. The toxicity of the compounds was evaluated in vitro with lactate dehydrogenase (LDH) assay. All of the compounds-especially 1-stimulated LDH release in primary cultured rat myocardial cells, an effect that was blocked by the Na
Identifiants
pubmed: 30529612
pii: S0147-6513(18)31254-5
doi: 10.1016/j.ecoenv.2018.11.109
pii:
doi:
Substances chimiques
Diterpene Alkaloids
0
Phytochemicals
0
Plant Extracts
0
Lidocaine
98PI200987
L-Lactate Dehydrogenase
EC 1.1.1.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
141-147Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.