Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD.
5-alpha-Dihydroprogesterone
/ analysis
Adult
Cholestenone 5 alpha-Reductase
Dehydroepiandrosterone
/ analysis
Dehydroepiandrosterone Sulfate
/ analysis
Depressive Disorder, Major
/ metabolism
GABAergic Neurons
/ pathology
Gas Chromatography-Mass Spectrometry
/ methods
Humans
Hydroxysteroid Dehydrogenases
Male
Middle Aged
Neurosteroids
/ cerebrospinal fluid
Pregnanolone
/ analysis
Progesterone
/ analysis
Severity of Illness Index
Stress Disorders, Post-Traumatic
/ metabolism
Allopregnanolone
Cerebrospinal fluid
Dehydroepiandrosterone
Depression
GABA
Gas chromatography-mass spectrometry
Neurosteroids
PTSD
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
09
08
2018
revised:
02
11
2018
accepted:
21
11
2018
pubmed:
12
12
2018
medline:
18
3
2020
entrez:
12
12
2018
Statut:
ppublish
Résumé
Allopregnanolone and pregnanolone (together termed allo + pregnan) are neurosteroid metabolites of progesterone that equipotently facilitate the action of gamma-amino-butyric acid (GABA) at GABA
Identifiants
pubmed: 30529908
pii: S0306-4530(18)30820-5
doi: 10.1016/j.psyneuen.2018.11.027
pmc: PMC6584957
mid: NIHMS1035437
pii:
doi:
Substances chimiques
Neurosteroids
0
Dehydroepiandrosterone
459AG36T1B
Progesterone
4G7DS2Q64Y
Dehydroepiandrosterone Sulfate
57B09Q7FJR
5-alpha-Dihydroprogesterone
98G4S1OH0Z
Pregnanolone
BXO86P3XXW
Hydroxysteroid Dehydrogenases
EC 1.1.-
Cholestenone 5 alpha-Reductase
EC 1.3.1.22
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-104Subventions
Organisme : NICHD NIH HHS
ID : K23 HD087428
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.
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