Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria.
Adenosine Triphosphate
/ metabolism
Anti-Bacterial Agents
/ pharmacology
Antitubercular Agents
/ pharmacology
Bacterial Proteins
/ antagonists & inhibitors
Drug Design
Electron Transport Chain Complex Proteins
/ antagonists & inhibitors
Energy Metabolism
/ drug effects
Isoniazid
/ pharmacology
Moxifloxacin
/ pharmacology
Mycobacterium
/ cytology
Oxidative Phosphorylation
/ drug effects
Proton-Translocating ATPases
/ antagonists & inhibitors
ATP
Bedaquiline
Mycobacterium tuberculosis
Q203
Telacebec
antagonism
antibiotics
cell death
oxidative phosphorylation
tuberculosis
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 02 2019
08 02 2019
Historique:
received:
06
09
2018
revised:
29
11
2018
pubmed:
12
12
2018
medline:
14
5
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Energy metabolism has recently gained interest as a target space for antibiotic drug development in mycobacteria. Of particular importance is bedaquiline (Sirturo), which kills mycobacteria by inhibiting the F
Identifiants
pubmed: 30530783
pii: S0021-9258(20)36840-X
doi: 10.1074/jbc.RA118.005732
pmc: PMC6369303
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antitubercular Agents
0
Bacterial Proteins
0
Electron Transport Chain Complex Proteins
0
Adenosine Triphosphate
8L70Q75FXE
Proton-Translocating ATPases
EC 3.6.3.14
Moxifloxacin
U188XYD42P
Isoniazid
V83O1VOZ8L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1936-1943Subventions
Organisme : NIAID NIH HHS
ID : F30 AI138483
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139465
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007288
Pays : United States
Informations de copyright
© 2019 Lee et al.
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