Multimodal magnetic resonance imaging investigation of basal forebrain damage and cognitive deficits in Parkinson's disease.
Aged
Basal Forebrain
/ diagnostic imaging
Brain Mapping
Cognition
/ physiology
Cognitive Dysfunction
/ diagnostic imaging
Executive Function
/ physiology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multimodal Imaging
Neural Pathways
/ diagnostic imaging
Neuropsychological Tests
Parkinson Disease
/ complications
acetylcholine
cholinergic
cognition
diffusion MRI
functional connectivity
resting state fMRI
Journal
Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Titre abrégé: Mov Disord
Pays: United States
ID NLM: 8610688
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
21
05
2018
revised:
22
10
2018
accepted:
23
10
2018
pubmed:
12
12
2018
medline:
10
1
2020
entrez:
12
12
2018
Statut:
ppublish
Résumé
Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4). We investigated changes in basal forebrain and their role in cognitive deficits in PD. We studied 52 nondemented patients with PD (Hoehn & Yahr 1-2) and 25 age-matched healthy controls using diffusion and resting state functional MRI. PD patients had a loss of structural integrity within the Ch1-2 and Ch3-4 nuclei of the basal forebrain as well as in the fornix. Tractography showed that the probability of anatomical connection was decreased in PD between Ch3-4 and the associative prefrontal cortex, occipital cortex, and peri-insular regions. There was a reduction in functional connectivity between Ch1-2 and the bilateral hippocampi and parahippocampal gyri, the left middle and superior temporal gyri, and the left fusiform gyrus and between Ch3-4 and the right inferior frontal gyrus and the right and left thalamus. In Ch1-2, loss of structural integrity and connectivity correlated with scores at the memory tests, whereas changes in Ch3-4 correlated with scores of global cognition and executive functions. This study highlights the association between deficits of different cholinergic nuclei of the basal forebrain and the extent of cognitive impairments in nondemented PD patients. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Sections du résumé
BACKGROUND
Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4).
OBJECTIVE
We investigated changes in basal forebrain and their role in cognitive deficits in PD.
METHODS
We studied 52 nondemented patients with PD (Hoehn & Yahr 1-2) and 25 age-matched healthy controls using diffusion and resting state functional MRI.
RESULTS
PD patients had a loss of structural integrity within the Ch1-2 and Ch3-4 nuclei of the basal forebrain as well as in the fornix. Tractography showed that the probability of anatomical connection was decreased in PD between Ch3-4 and the associative prefrontal cortex, occipital cortex, and peri-insular regions. There was a reduction in functional connectivity between Ch1-2 and the bilateral hippocampi and parahippocampal gyri, the left middle and superior temporal gyri, and the left fusiform gyrus and between Ch3-4 and the right inferior frontal gyrus and the right and left thalamus. In Ch1-2, loss of structural integrity and connectivity correlated with scores at the memory tests, whereas changes in Ch3-4 correlated with scores of global cognition and executive functions.
CONCLUSION
This study highlights the association between deficits of different cholinergic nuclei of the basal forebrain and the extent of cognitive impairments in nondemented PD patients. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Identifiants
pubmed: 30536444
doi: 10.1002/mds.27561
pmc: PMC6590238
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
516-525Subventions
Organisme : ANR Nucleipark
Pays : International
Organisme : DHOS-Inserm
Pays : International
Organisme : France Parkinson
Pays : International
Organisme : Ecole des NeuroSciences de Paris
Pays : International
Organisme : Fondation pour la Recherche Médicale
Pays : International
Organisme : Investissements d'Avenir
Pays : International
Organisme : IAIHU-06 (Paris Institute of Neurosciences-IHU)
ID : ANR-11-INBS-0006
Pays : International
Organisme : Fondation d'Entreprise EDF
Pays : International
Organisme : Fondation Thérèse
Pays : International
Organisme : René Planiol pour l'étude du Cerveau
Pays : International
Informations de copyright
© 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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