Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects.
acetylcholinesterase
carbonic anhydrase
enzyme inhibition
synthesis
thiophene
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
04
07
2018
revised:
10
09
2018
accepted:
24
10
2018
pubmed:
12
12
2018
medline:
2
5
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Novel substituted thiophene derivatives (1, 2a-e, 3, and 4) were synthesized and their structures were characterized by infrared radiation, nuclear magnetic resonance, and mass analysis. These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K
Substances chimiques
Carbonic Anhydrase Inhibitors
0
Cholinesterase Inhibitors
0
Thiophenes
0
Acetylcholinesterase
EC 3.1.1.7
Carbonic Anhydrase I
EC 4.2.1.-
Carbonic Anhydrase II
EC 4.2.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22261Informations de copyright
© 2018 Wiley Periodicals, Inc.