High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry.
DNA damage
Huntington disease
N17 domain
PY-NLS
ROS sensing
high-mobility group box protein
neurodegenerative disease
nuclear transport
oxidative stress
reactive oxygen species (ROS)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 02 2019
08 02 2019
Historique:
received:
12
12
2017
revised:
04
12
2018
pubmed:
13
12
2018
medline:
14
5
2019
entrez:
13
12
2018
Statut:
ppublish
Résumé
Huntington's disease (HD) is a neurodegenerative, age-onset disorder caused by a CAG DNA expansion in exon 1 of the
Identifiants
pubmed: 30538129
pii: S0021-9258(20)36838-1
doi: 10.1074/jbc.RA117.001440
pmc: PMC6369305
doi:
Substances chimiques
HMGB1 Protein
0
Huntingtin Protein
0
Nuclear Localization Signals
0
Nuclear Proteins
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1915-1923Subventions
Organisme : CIHR
ID : MOP-119391
Pays : Canada
Informations de copyright
© 2019 by The American Society for Biochemistry and Molecular Biology, Inc.
Références
Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14610-5
pubmed: 23898200
Nat Cell Biol. 2010 Jul;12(7):703-10
pubmed: 20526328
J Cell Biol. 2009 Dec 28;187(7):1083-99
pubmed: 20026656
J Neurochem. 1993 Jan;60(1):356-9
pubmed: 8417157
Ann N Y Acad Sci. 2010 Oct;1209:83-90
pubmed: 20958320
Hum Mol Genet. 2017 Aug 1;26(15):2882-2896
pubmed: 28481984
Commun Integr Biol. 2013 Mar 1;6(2):e23318
pubmed: 23750301
Hum Mol Genet. 2017 Jan 15;26(2):395-406
pubmed: 28017939
Oncotarget. 2017 May 16;8(38):64534-64550
pubmed: 28969092
Cell. 1993 Mar 26;72(6):971-83
pubmed: 8458085
Neuron. 2009 Dec 24;64(6):828-40
pubmed: 20064390
Nat Cell Biol. 2007 Apr;9(4):402-14
pubmed: 17384639
Nat Neurosci. 2017 Sep;20(9):1225-1235
pubmed: 28714954
Cell. 2015 Jul 30;162(3):516-26
pubmed: 26232222
J Huntingtons Dis. 2015;4(3):279-84
pubmed: 26444025
J Neurosci. 2001 Mar 15;21(6):1830-7
pubmed: 11245667
Biophys J. 2013 Aug 6;105(3):699-710
pubmed: 23931318
Cell Metab. 2011 Jun 8;13(6):701-11
pubmed: 21641551
Lancet Neurol. 2017 Sep;16(9):701-711
pubmed: 28642124
Antioxid Redox Signal. 2011 Apr 1;14(7):1315-35
pubmed: 20969478
Nat Chem Biol. 2011 May 29;7(7):453-60
pubmed: 21623356
Biochem Biophys Res Commun. 2013 Nov 29;441(4):701-6
pubmed: 24427810
Brain Nerve. 2017 Aug;69(8):925-932
pubmed: 28819076
Eur J Biochem. 1977 Sep;78(2):497-502
pubmed: 913411
Hum Mol Genet. 2015 Jan 15;24(2):450-62
pubmed: 25205111
Hum Mol Genet. 2013 Apr 1;22(7):1383-94
pubmed: 23297360
PLoS One. 2015 Dec 14;10(12):e0144864
pubmed: 26660732
PLoS Biol. 2017 Aug 4;15(8):e2002063
pubmed: 28777795
J Biol Chem. 2002 Mar 1;277(9):7021-8
pubmed: 11748221
PLoS Biol. 2008 Jun 3;6(6):e137
pubmed: 18532879
J Biol Chem. 2012 Nov 16;287(47):39626-33
pubmed: 23012356
J Biol Chem. 1995 Oct 27;270(43):25752-61
pubmed: 7592757
Biochemistry. 2004 Sep 28;43(38):11992-7
pubmed: 15379539
J Cell Biol. 2010 Sep 6;190(5):881-92
pubmed: 20819940
Hum Mol Genet. 2007 Nov 1;16(21):2600-15
pubmed: 17704510
Biochim Biophys Acta. 2016 Nov;1864(11):1620-9
pubmed: 27476953
Genes Dev. 1998 Feb 15;12(4):462-72
pubmed: 9472015
EMBO Mol Med. 2014 Dec 15;7(1):78-101
pubmed: 25510912
Oncogene. 2006 Jan 5;25(1):1-7
pubmed: 16278683
Science. 1997 Sep 26;277(5334):1990-3
pubmed: 9302293
J Biol Chem. 2009 Oct 23;284(43):29427-36
pubmed: 19710014
J Leukoc Biol. 2007 Mar;81(3):741-7
pubmed: 17135572
Hum Mol Genet. 2016 Sep 15;25(18):3937-3945
pubmed: 27466181
Mol Biol Cell. 2018 Nov 15;29(23):2809-2820
pubmed: 30256717