The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.
Animals
Apoptosis
/ drug effects
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Female
Focal Adhesion Protein-Tyrosine Kinases
/ antagonists & inhibitors
Humans
Lung Neoplasms
/ drug therapy
Mesothelioma
/ drug therapy
Mesothelioma, Malignant
Mice, SCID
Pleural Neoplasms
/ drug therapy
Protein Kinase Inhibitors
/ therapeutic use
Spheroids, Cellular
/ drug effects
Tumor Cells, Cultured
Angiogenesis
Focal adhesion kinase
Mesothelioma
Orthotopic xenograft
Spheroid formation
Tyrosine kinase inhibitor
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
12
06
2018
accepted:
19
11
2018
revised:
16
11
2018
pubmed:
13
12
2018
medline:
28
5
2020
entrez:
13
12
2018
Statut:
ppublish
Résumé
No tyrosine kinase inhibitors are approved for malignant pleural mesothelioma (MPM). Preclinical studies identified focal adhesion kinase (FAK) as a target in MPM. Accordingly, we assessed the novel, highly selective FAK inhibitor (BI 853520) in 2D and 3D cultures and in vivo. IC
Identifiants
pubmed: 30539198
doi: 10.1007/s00109-018-1725-7
pii: 10.1007/s00109-018-1725-7
pmc: PMC6348072
doi:
Substances chimiques
Protein Kinase Inhibitors
0
Focal Adhesion Protein-Tyrosine Kinases
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
231-242Subventions
Organisme : Austrian Science Fund FWF
ID : I 2872
Pays : Austria
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