1,25‑Dihydroxyvitamin D regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing miR-125b.
Animals
Cell Differentiation
Cells, Cultured
Colitis
/ drug therapy
Cytokines
/ metabolism
Dihydroxycholecalciferols
/ therapeutic use
Disease Models, Animal
Humans
Immunologic Factors
/ therapeutic use
Inflammation
/ drug therapy
Inflammatory Bowel Diseases
/ drug therapy
Leukocytes, Mononuclear
/ physiology
Lipopolysaccharides
/ immunology
Macrophages
/ physiology
Male
Mice
Mice, Inbred C57BL
MicroRNAs
/ genetics
RNA, Small Interfering
/ genetics
Receptors, Calcitriol
/ genetics
Th2 Cells
/ immunology
1,25(OH)(2)D(3)
Colitis
IBD
Macrophage
miR-125b
Journal
International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
20
09
2018
revised:
03
12
2018
accepted:
04
12
2018
pubmed:
13
12
2018
medline:
6
5
2019
entrez:
13
12
2018
Statut:
ppublish
Résumé
Macrophages are highly plastic cells. Depending on stimulation, macrophages rapidly polarize to functionally distinct phenotypes that are involved in the pathogenesis of inflammatory bowel disease (IBD). 1,25‑Dihydroxyvitamin D (1,25(OH)
Identifiants
pubmed: 30540970
pii: S1567-5769(18)30706-9
doi: 10.1016/j.intimp.2018.12.015
pii:
doi:
Substances chimiques
Cytokines
0
Dihydroxycholecalciferols
0
Immunologic Factors
0
Lipopolysaccharides
0
MicroRNAs
0
Mirn125 microRNA, mouse
0
RNA, Small Interfering
0
Receptors, Calcitriol
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106-118Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.