Gelatin hydrogel containing cerium oxide nanoparticles covered by interleukin-17 aptamar as an anti- inflammatory agent for brain inflammation.
Animals
Anti-Inflammatory Agents
/ pharmacology
Aptamers, Peptide
Brain
/ drug effects
Cerium
Cholinesterase Inhibitors
/ toxicity
Drug Carriers
/ chemistry
Encephalitis
/ chemically induced
Female
Hydrogels
Inflammation
/ chemically induced
Interleukin-17
Mice
Mice, Inbred C57BL
Nanoparticles
Parathion
/ toxicity
Aptamer
Brain inflammation
Cerium oxide
Nanoparticles
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
02
08
2018
revised:
28
08
2018
accepted:
21
11
2018
pubmed:
14
12
2018
medline:
30
11
2019
entrez:
14
12
2018
Statut:
ppublish
Résumé
The purpose of this study was to evaluate the anti-inflammatory property of gelatin hydrogel containing cerium oxide nanoparticles coated with interleukin-17 Aptemer ([CeON@IL-17]). Here, the brain inflammation model was induced by both proteolipid protein (PLP) and parathion. Then, the expression of some inflammatory genes and the serum level of related interleukins were evaluated. This study showed that the expression of IL-17, IL-10, and IL-6 genes and their serum levels were significantly decreased (P < .05) by administration of gelatin hydrogel containing [CeON@IL-17].
Identifiants
pubmed: 30544018
pii: S0165-5728(18)30360-6
doi: 10.1016/j.jneuroim.2018.11.011
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Aptamers, Peptide
0
Cholinesterase Inhibitors
0
Drug Carriers
0
Hydrogels
0
Interleukin-17
0
Cerium
30K4522N6T
ceric oxide
619G5K328Y
Parathion
61G466064D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-83Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.