The neurobiological basis of narcolepsy.
Journal
Nature reviews. Neuroscience
ISSN: 1471-0048
Titre abrégé: Nat Rev Neurosci
Pays: England
ID NLM: 100962781
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
14
12
2018
medline:
18
12
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery about 20 years ago that narcolepsy is caused by selective loss of the neurons producing orexins (also known as hypocretins) sparked great advances in the field. Here, we review the current understanding of how orexin neurons regulate sleep-wake behaviour and the consequences of the loss of orexin neurons. We also summarize the developing evidence that narcolepsy is an autoimmune disorder that may be caused by a T cell-mediated attack on the orexin neurons and explain how these new perspectives can inform better therapeutic approaches.
Identifiants
pubmed: 30546103
doi: 10.1038/s41583-018-0097-x
pii: 10.1038/s41583-018-0097-x
pmc: PMC6492289
mid: NIHMS1017577
doi:
Substances chimiques
Orexins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-93Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL095491
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106032
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS099787
Pays : United States
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