6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M

Allosteric Regulation / drug effects Animals CHO Cells Cells, Cultured Cricetinae Cricetulus Crystallography, X-Ray / methods Mice Pyrimidines / chemical synthesis Quinolines / chemical synthesis Receptor, Muscarinic M1 / agonists
Alzheimer’s disease BQCA M1 muscarinic acetylcholine receptor positive allosteric modulator pyrimidinones schizophrenia

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
20 03 2019
Historique:
pubmed: 15 12 2018
medline: 7 3 2020
entrez: 15 12 2018
Statut: ppublish

Résumé

Targeting allosteric sites of the M

Identifiants

DOI: 10.1021/acschemneuro.8b00613 PMID: 30547573
pubmed: 30547573
doi: 10.1021/acschemneuro.8b00613
doi:

Substances chimiques

1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 0
Pyrimidines 0
Quinolines 0
Receptor, Muscarinic M1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1099-1114

Subventions

Organisme : Medical Research Council
ID : MR/P019366/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201529/Z/16/Z
Pays : United Kingdom

Auteurs

Manuela Jörg (M)

ORCID: 0000-0002-3116-373X

Emma T van der Westhuizen (ET)

Elham Khajehali (E)

Wessel A C Burger (WAC)

Jonathan M White (JM)

Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , 30 Flemington Road , Parkville 3010 , VIC , Australia.
ORCID: 0000-0002-0707-6257

Kwok H C Choy (KHC)

Andrew B Tobin (AB)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences , University of Glasgow , Glasgow G12 8QQ , United Kingdom.
ORCID: 0000-0002-1807-3123

Patrick M Sexton (PM)

ORCID: 0000-0001-8902-2473

Celine Valant (C)

Ben Capuano (B)

ORCID: 0000-0001-5434-0180

Arthur Christopoulos (A)

Peter J Scammells (PJ)

ORCID: 0000-0003-2930-895X

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Eucaryotes › Animaux › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Cellules › Cellules cultivées › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › 6-Phenylpyrimidin-4-ones as Positive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M1 › 6-Phenylpyrimidin-4-ones as Positive...