Brain iron deposition in primary insomnia-An in vivo susceptibility-weighted imaging study.
Activities of Daily Living
Adult
Aged
Brain
/ diagnostic imaging
China
Cognitive Dysfunction
/ diagnosis
Correlation of Data
Female
Hippocampus
/ diagnostic imaging
Humans
Iron
/ metabolism
Iron Metabolism Disorders
/ complications
Magnetic Resonance Imaging
/ methods
Male
Mental Status and Dementia Tests
Middle Aged
Reproducibility of Results
Sleep Initiation and Maintenance Disorders
/ diagnosis
MRI
cognitive impairment
iron deposition
primary insomnia
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
05
03
2017
revised:
25
06
2018
accepted:
01
07
2018
pubmed:
15
12
2018
medline:
31
7
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
To study the brain iron deposition and its relationships with cognitive impairment and sleep quality in primary insomnia (PI). Thirty-five patients with PI and 35 volunteers underwent MRI scanning using high-resolution susceptibility-weighted imaging sequence. Bilateral anterior cingulate cortices, posterior cingulate cortex, hippocampus, caudate nucleus, globus pallidus, putamen, thalamus, red nucleus, substantia nigra, parietal cortex, and frontal white matter were selected as regions of interest. The phase shift values of the above areas were compared between the two groups. Partial correlations between phase shifts values and neuropsychological scale scores including Pittsburgh Sleep Quality Index, Insomnia Severity Index, Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Scale, and Clinical Dementia Rating of the PI patients were analyzed. Compared with the normal controls, the PI patients showed significant lower MMSE and MoCA scores and increased phase shift values in the left caudate nucleus, left putamen, left hippocampus, and bilateral thalamus (p < 0.05). Close correlation was found between the phase shift value of the left hippocampus and the MMSE scores of the PI patients (R = -0.447, p < 0.01). The PI patients exhibited significant cognitive impairment and increased iron deposition in several brain regions. The iron concentration of the left hippocampus is a biomarker of cognitive impairment and may play an important role in the pathophysiological mechanism.
Sections du résumé
BACKGROUND
To study the brain iron deposition and its relationships with cognitive impairment and sleep quality in primary insomnia (PI).
METHODS
Thirty-five patients with PI and 35 volunteers underwent MRI scanning using high-resolution susceptibility-weighted imaging sequence. Bilateral anterior cingulate cortices, posterior cingulate cortex, hippocampus, caudate nucleus, globus pallidus, putamen, thalamus, red nucleus, substantia nigra, parietal cortex, and frontal white matter were selected as regions of interest. The phase shift values of the above areas were compared between the two groups. Partial correlations between phase shifts values and neuropsychological scale scores including Pittsburgh Sleep Quality Index, Insomnia Severity Index, Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Scale, and Clinical Dementia Rating of the PI patients were analyzed.
RESULTS
Compared with the normal controls, the PI patients showed significant lower MMSE and MoCA scores and increased phase shift values in the left caudate nucleus, left putamen, left hippocampus, and bilateral thalamus (p < 0.05). Close correlation was found between the phase shift value of the left hippocampus and the MMSE scores of the PI patients (R = -0.447, p < 0.01).
CONCLUSION
The PI patients exhibited significant cognitive impairment and increased iron deposition in several brain regions. The iron concentration of the left hippocampus is a biomarker of cognitive impairment and may play an important role in the pathophysiological mechanism.
Identifiants
pubmed: 30548431
doi: 10.1002/brb3.1138
pmc: PMC6346654
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e01138Informations de copyright
© 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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