BDNF
Animals
Brain
/ metabolism
Brain-Derived Neurotrophic Factor
/ genetics
Depressive Disorder, Major
/ genetics
Female
Heterozygote
Male
Nerve Tissue Proteins
/ genetics
Neuregulin-1
/ genetics
Phenotype
Rats
Rats, Sprague-Dawley
Receptors, Glucocorticoid
/ genetics
Tacrolimus Binding Proteins
/ genetics
Disc1
Fkbp5
GR
Nrg1
anhedonia
anxiety
brain-derived neurotrophic factor
hippocampus
prefrontal cortex
transgenic rats
Journal
Genes, brain, and behavior
ISSN: 1601-183X
Titre abrégé: Genes Brain Behav
Pays: England
ID NLM: 101129617
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
10
07
2018
revised:
06
12
2018
accepted:
07
12
2018
pubmed:
15
12
2018
medline:
22
3
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
Major depressive disorder (MDD) is a leading contributor to the global burden of disease. However, the causal relationship of risk factors, such as genetic predisposition or experience of augmented stress, remain unknown. Numerous studies in humans and rodents have implicated brain-derived neurotrophic factor (BDNF) in MDD pathology, as a genetic risk factor and a factor regulated by stress. Until now, the majority of preclinical studies have employed genetically modified mice as their model of choice. However, mice display a limited behavioural repertoire and lack expression of circulating BDNF, which is present in rats and humans. Therefore, heterozygous BDNF (BDNF
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Disc1 protein, rat
0
Nerve Tissue Proteins
0
Neuregulin-1
0
Receptors, Glucocorticoid
0
Tacrolimus Binding Proteins
EC 5.2.1.-
tacrolimus binding protein 5
EC 5.2.1.8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12546Subventions
Organisme : Medical Research Council
ID : MR/K026992/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
© 2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.