Anti-psoriatic effect of myeloid-derived suppressor cells on imiquimod-induced skin inflammation in mice.
imiquimod
immunomodulation
myeloid-derived suppressor cells
psoriasis
Journal
Scandinavian journal of immunology
ISSN: 1365-3083
Titre abrégé: Scand J Immunol
Pays: England
ID NLM: 0323767
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
22
08
2018
revised:
07
11
2018
accepted:
06
12
2018
pubmed:
15
12
2018
medline:
8
3
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
Myeloid-derived suppressor cells (MDSCs) play an important role in controlling the immune response against cancer and in suppression of autoimmunity and allergic inflammation. However, the beneficial effects of MDSCs on the experimental mouse model of psoriasis have not been reported. Therefore, we investigated the anti-psoriatic effect of MDSCs on IMQ-induced skin inflammation in mice and explored the mechanisms involved. Our results showed that administration of MDSCs (1 × 10
Substances chimiques
Cytokines
0
Imiquimod
P1QW714R7M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12742Subventions
Organisme : National Research Foundation
Organisme : Ministry of Education
ID : NRF-2016R1D1A1B03934099
Organisme : Ministry of Education
ID : NRF-2013R1A1A2065795
Informations de copyright
© 2018 The Foundation for the Scandinavian Journal of Immunology.