An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC-QTOF-MS method.
Animals
Chromatography, High Pressure Liquid
/ methods
Drug Stability
Herb-Drug Interactions
Limit of Detection
Linear Models
Male
Piperazines
/ blood
Plant Extracts
/ pharmacology
Pyridines
/ blood
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/ methods
Tea
/ chemistry
UHPLC-QTOF-MS
green tea extracts
palbociclib
protein precipitation
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
28
09
2018
revised:
04
12
2018
accepted:
10
12
2018
pubmed:
15
12
2018
medline:
9
4
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
Green tea extracts (GTE) has been reported to be a kinase inhibitor and modulator for various drug metabolizing enzymes. It may give synergetic antioncogenic effect, but with a possibility of pharmacokinetic interactions with various co-administered anticancer agents like palbociclib (PAL), a selective inhibitor of CDK-4/6 primarily metabolized by CYP3A enzyme. To explore the impact of GTE on PAL pharmacokinetics in Sprague-Dawley rats, a rapid and sensitive UHPLC-QTOF-MS method was established. Chromatographic separation was carried out on an Acquity UPLC BEH C
Substances chimiques
Piperazines
0
Plant Extracts
0
Pyridines
0
Tea
0
palbociclib
G9ZF61LE7G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e4469Informations de copyright
© 2018 John Wiley & Sons, Ltd.