Age but no sex effects on subareas of the amygdala.
MRI
aging
amygdala
brain
gender
sex
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
07
04
2018
revised:
23
10
2018
accepted:
07
11
2018
pubmed:
15
12
2018
medline:
9
4
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
The amygdala, an anatomical composite of several nuclei that have been grouped anatomically and functionally into three major subareas, has been reported to decrease in size with increasing age and to differ in size between male and female brains. However, findings are rather inconsistent across existing studies, possibly reflecting differences in the cohorts examined or the approaches chosen to define and measure the dimensions of the amygdala. Here, we investigated possible effects of age and sex on the amygdala as well as age-by-sex interactions in 100 healthy subjects (50 men/50 women) aged 18-69 years. For this purpose, we enhanced conventional imaging-based information with microscopically defined cytoarchitectonic probabilities to discriminate between different subareas. We observed significant negative correlations between age and all subareas of the amygdala indicating decreases over time, but with subarea-specific trajectories. In addition, we detected a significant quadratic association with age for the left superficial subarea suggesting an accelerating volume loss over time. Such regional information may serve as a frame of reference in future studies, not only for normative samples but also potentially for clinical populations known to present with an atypical atrophy of the amygdala. There were no sex differences and no interactions between sex and age, suggesting that the size of the amygdala is similar in male and female brains (at least when properly accounting for total intracranial volume) and that its age-related decline follows a similar trajectory in both sexes.
Identifiants
pubmed: 30549129
doi: 10.1002/hbm.24481
pmc: PMC6865643
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1697-1704Subventions
Organisme : NICHD NIH HHS
ID : R01 HD081720
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01HD081720
Pays : International
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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