Maternal vaccination with a novel chimeric glycoprotein formulated with a polymer-based adjuvant provides protection from human parainfluenza virus type 3 in newborn lambs.
Adjuvants, Immunologic
/ administration & dosage
Animals
Animals, Newborn
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
Female
Glycoproteins
/ genetics
Humans
Immunity, Maternally-Acquired
Parainfluenza Vaccines
/ administration & dosage
Parainfluenza Virus 3, Human
/ immunology
Pregnancy
Respiratory Syncytial Viruses
/ genetics
Respirovirus Infections
/ immunology
Sheep
Vaccines, Subunit
/ administration & dosage
Viral Fusion Proteins
/ administration & dosage
Animal model
Maternal antibodies
Maternal vaccination
Newborn lambs
Parainfluenza virus-3
Respiratory syncytial virus
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
03
08
2018
revised:
11
11
2018
accepted:
11
12
2018
pubmed:
15
12
2018
medline:
11
2
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
Human parainfluenza virus 3 (PIV3) and respiratory syncytial virus (RSV) are major causative agents of serious respiratory tract illness in newborns and infants. Maternal vaccination could be a promising approach to provide immediate protection against severe PIV3 and RSV infection in young infants. Previously, we demonstrated that maternal immunization with a subunit vaccine consisting of the RSV fusion (F) protein formulated with TriAdj, an adjuvant consisting of poly(I:C), immune defense regulatory peptide and polyphosphazene, protects newborn lambs from RSV. In the present study we evaluated the protective efficacy of a novel bivalent RSV-PIV3 vaccine candidate, F
Identifiants
pubmed: 30550799
pii: S0166-3542(18)30464-9
doi: 10.1016/j.antiviral.2018.12.010
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Glycoproteins
0
Parainfluenza Vaccines
0
Vaccines, Subunit
0
Viral Fusion Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
54-60Subventions
Organisme : CIHR
ID : MOP 119473
Pays : Canada
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.