In Vivo Preclinical Molecular Imaging of Repeated Exposure to an
Animals
Dizocilpine Maleate
/ pharmacology
Drug Evaluation, Preclinical
/ methods
Excitatory Amino Acid Antagonists
/ pharmacology
Glutamic Acid
/ metabolism
Glutaminase
/ antagonists & inhibitors
Glutamine
/ metabolism
Male
Molecular Imaging
/ methods
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate
/ antagonists & inhibitors
Journal
The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
03
08
2018
accepted:
19
11
2018
pubmed:
16
12
2018
medline:
2
11
2019
entrez:
16
12
2018
Statut:
ppublish
Résumé
Glutamate is the principal excitatory neurotransmitter in the brain and is at the base of a wide variety of neuropathologies, including epilepsy, autism, Fragile X, and obsessive compulsive disorder. Glutamate has also become the target for novel drugs in treatment and in fundamental research settings. However, much remains unknown on the working mechanisms of these drugs and the effects of chronic administration on the glutamatergic system. This study investigated the chronic effects of two glutamate-modulating drugs with imaging techniques to further clarify their working mechanisms for future research opportunities. Animals were exposed to saline (1 ml/kg), (5
Identifiants
pubmed: 30552293
pii: jpet.118.252635
doi: 10.1124/jpet.118.252635
doi:
Substances chimiques
Excitatory Amino Acid Antagonists
0
Receptors, N-Methyl-D-Aspartate
0
Glutamine
0RH81L854J
Glutamic Acid
3KX376GY7L
Dizocilpine Maleate
6LR8C1B66Q
Glutaminase
EC 3.5.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
382-390Informations de copyright
Copyright © 2019 by The Author(s).