Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.
Adenocarcinoma
/ genetics
Antineoplastic Agents, Immunological
/ therapeutic use
Carcinoma, Adenoid Cystic
/ genetics
Carcinoma, Ductal
/ genetics
Carcinoma, Mucoepidermoid
/ genetics
DNA Mutational Analysis
Gene Expression Profiling
Humans
Mutation
Salivary Ducts
/ pathology
Salivary Gland Neoplasms
/ genetics
head and neck cancer
immunotherapy
molecular targeted therapy
salivary gland cancer
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
12
04
2018
revised:
11
06
2018
accepted:
05
07
2018
pubmed:
16
12
2018
medline:
28
5
2020
entrez:
16
12
2018
Statut:
ppublish
Résumé
Salivary gland cancers represent a rare group of tumors composed by over 20 histological subtypes. Initially treated as one single disease, its diagnosis, prognosis, and treatment are currently being stratified based on morphology. More recently, insight has been provided on the molecular characterization of each subtype, further improving diagnostic accuracy and paving the way for personalized therapy. In this article, we provide a comprehensive review of recent breakthroughs, preliminary results of novel therapy, and future directions on the treatment of these complex malignancies.
Substances chimiques
Antineoplastic Agents, Immunological
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-247Informations de copyright
© 2018 Wiley Periodicals, Inc.