Pathophysiological mechanisms implicated in postpartum depression.
Allopregnanolone
Circuit dysfunction
Epigenetics
GABA
HPA axis
Neuroinflammation
Oscillations
Postpartum depression
Stress
Journal
Frontiers in neuroendocrinology
ISSN: 1095-6808
Titre abrégé: Front Neuroendocrinol
Pays: United States
ID NLM: 7513292
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
07
08
2018
revised:
13
11
2018
accepted:
11
12
2018
pubmed:
16
12
2018
medline:
18
5
2019
entrez:
16
12
2018
Statut:
ppublish
Résumé
This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinnings. The evidence supporting a role for neuroendocrine changes, neuroinflammation, neurotransmitter alterations, circuit dysfunction, and the involvement of genetics and epigenetics in the pathophysiology of postpartum depression are discussed. This review integrates clinical and preclinical findings and highlights the diversity in the patient population, in which numerous pathophysiological changes may contribute to this disorder. Finally, we attempt to integrate these findings to understand how diverse neurobiological changes may contribute to a common pathological phenotype. This review is meant to serve as a comprehensive resource reviewing the proposed pathophysiological mechanisms underlying postpartum depression.
Identifiants
pubmed: 30552910
pii: S0091-3022(18)30074-8
doi: 10.1016/j.yfrne.2018.12.001
pmc: PMC6370514
mid: NIHMS1517305
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
165-180Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102937
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104262
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112704
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073574
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026256
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
Références
Br Med Bull. 2012;101:57-79
pubmed: 22130907
J Midwifery Womens Health. 2014 Jan-Feb;59(1):35-42: quiz 108
pubmed: 24472136
Horm Behav. 2008 Jun;54(1):203-11
pubmed: 18423635
Neuropsychopharmacology. 2011 Aug;36(9):1886-93
pubmed: 21562482
Arch Womens Ment Health. 2013 Aug;16(4):339-40
pubmed: 23636476
Front Psychiatry. 2011 May 09;2:23
pubmed: 21629844
Behav Brain Res. 2001 Jul;122(1):1-9
pubmed: 11287071
Obstet Gynecol. 2011 Aug;118(2 Pt 1):214-221
pubmed: 21734617
J Neurosci. 2009 Jul 29;29(30):9592-601
pubmed: 19641122
J Clin Endocrinol Metab. 1996 May;81(5):1912-7
pubmed: 8626857
J Psychiatr Res. 2010 Aug;44(11):717-24
pubmed: 20092830
Neuropsychopharmacology. 2006 Jun;31(6):1097-111
pubmed: 16554740
J Womens Health (Larchmt). 2012 Mar;21(3):264-72
pubmed: 22204416
Psychoneuroendocrinology. 2000 Feb;25(2):121-37
pubmed: 10674277
Psychoneuroendocrinology. 2009 Oct;34(9):1329-37
pubmed: 19427131
Neuropsychobiology. 2014;69(3):147-53
pubmed: 24776841
Neuropsychopharmacology. 2016 May;41(6):1648-58
pubmed: 26503311
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Jun 30;34(5):766-76
pubmed: 19751794
Exp Neurobiol. 2014 Mar;23(1):28-35
pubmed: 24737937
Soc Neurosci. 2012;7(3):252-68
pubmed: 21943083
J Affect Disord. 1993 Oct-Nov;29(2-3):201-11
pubmed: 8300979
J Womens Health (Larchmt). 2013 Apr;22(4):352-61
pubmed: 23586800
J Psychiatr Res. 2013 Sep;47(9):1166-73
pubmed: 23726670
World J Biol Psychiatry. 2016;17(2):147-58
pubmed: 26813412
J Neurosci. 2009 Feb 11;29(6):1755-65
pubmed: 19211882
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3239-44
pubmed: 9501247
Horm Behav. 2017 Aug;94:106-113
pubmed: 28666923
Pediatrics. 2003 Jul;112(1 Pt 1):108-15
pubmed: 12837875
Physiol Behav. 1989 May;45(5):1067-8
pubmed: 2780868
Genes Brain Behav. 2016 Sep;15(7):678-88
pubmed: 27470444
Biol Psychiatry. 2006 Jun 15;59(12):1151-9
pubmed: 16566899
Biol Psychiatry. 2000 May 15;47(10):858-63
pubmed: 10807958
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1250-4
pubmed: 19625011
CNS Spectr. 2005 Oct;10(10):792-9, 805
pubmed: 16400241
Behav Pharmacol. 2015 Oct;26(7 Spec No):642-53
pubmed: 26061353
Depress Anxiety. 2018 Feb;35(2):160-167
pubmed: 29172228
Horm Behav. 2012 Mar;61(3):293-303
pubmed: 22100184
Nat Rev Neurosci. 2007 Jan;8(1):45-56
pubmed: 17180162
J Affect Disord. 2007 Jan;97(1-3):145-54
pubmed: 16863660
Behav Neurosci. 1991 Oct;105(5):663-8
pubmed: 1815617
Arch Womens Ment Health. 2010 Jun;13(3):285-9
pubmed: 20169377
Biol Psychol. 1994 Jul;37(3):199-206
pubmed: 7948465
J Neuroendocrinol. 2013 Feb;25(2):119-30
pubmed: 22935038
Psychoneuroendocrinology. 2016 Jul;69:150-60
pubmed: 27108164
Arch Gen Psychiatry. 2006 Nov;63(11):1209-16
pubmed: 17088501
Psychoneuroendocrinology. 1998 Jul;23(5):465-75
pubmed: 9802121
Arch Gen Psychiatry. 1977 Jan;34(1):98-111
pubmed: 319772
Genes Brain Behav. 2014 Sep;13(7):579-91
pubmed: 25077934
Life Sci. 2002 Sep 6;71(16):1837-48
pubmed: 12175700
CNS Spectr. 2007 Nov;12(11):853-62
pubmed: 17984858
Br J Psychiatry. 1989 May;154:660-7
pubmed: 2597859
Arch Gen Psychiatry. 2010 May;67(5):468-74
pubmed: 20439828
Arch Womens Ment Health. 2013 Dec;16(6):499-509
pubmed: 23917948
Arch Womens Ment Health. 2014 Jun;17(3):213-9
pubmed: 24663685
Br J Pharmacol. 2014 Oct;171(20):4539-55
pubmed: 24527704
Psychoneuroendocrinology. 2016 Aug;70:98-107
pubmed: 27209438
J Reprod Immunol. 2012 Jun;94(2):202-9
pubmed: 22386525
Biol Psychiatry. 1995 Dec 15;38(12):814-8
pubmed: 8750040
J Affect Disord. 2016 Mar 15;193:391-404
pubmed: 26802316
Neuropsychopharmacology. 2014 Jan;39(1):233-4
pubmed: 24317310
Neuropharmacology. 2015 Jan;88:91-8
pubmed: 25261782
J Abnorm Psychol. 1991 Feb;100(1):63-73
pubmed: 2005273
Arch Gen Psychiatry. 2009 Aug;66(8):917
pubmed: 19652134
Soc Cogn Affect Neurosci. 2014 Aug;9(8):1069-75
pubmed: 23709351
J Psychiatr Res. 2010 Jul;44(10):640-6
pubmed: 20045118
Psychoneuroendocrinology. 2018 Apr;90:182-193
pubmed: 29274662
Psychiatry Res Neuroimaging. 2017 Jul 30;265:18-25
pubmed: 28494346
J Psychiatry Neurosci. 2007 Jan;32(1):23-9
pubmed: 17245471
New Dir Child Dev. 1986 Winter;(34):61-82
pubmed: 3822211
Nature. 2013 Jan 24;493(7433):537-541
pubmed: 23235822
Arch Dis Child. 1997 Aug;77(2):99-101
pubmed: 9301345
Front Syst Neurosci. 2016 Jan 08;9:175
pubmed: 26778976
Int Breastfeed J. 2007 Mar 30;2:6
pubmed: 17397549
Fertil Steril. 2008 Mar;89(3):685-92
pubmed: 17543959
Mol Psychiatry. 2006 Mar;11(3):261-72
pubmed: 16344854
J Womens Health (Larchmt). 2012 Aug;21(8):830-6
pubmed: 22691031
Arch Womens Ment Health. 2011 Dec;14(6):453-63
pubmed: 21997575
Nat Genet. 2018 May;50(5):668-681
pubmed: 29700475
Biol Psychiatry. 2008 Aug 15;64(4):311-9
pubmed: 18471802
Nat Genet. 2006 Nov;38(11):1289-97
pubmed: 17013392
Depress Anxiety. 2017 Feb;34(2):137-146
pubmed: 28133901
J Psychiatr Res. 2013 Jun;47(6):816-28
pubmed: 23499388
Cochrane Database Syst Rev. 2008 Oct 08;(4):CD001690
pubmed: 18843619
Neuropeptides. 2013 Dec;47(6):363-70
pubmed: 24210135
Neuropsychopharmacology. 2015 Jan;40(2):429-35
pubmed: 25074638
J Clin Endocrinol Metab. 2005 Feb;90(2):695-9
pubmed: 15546899
Arch Gen Psychiatry. 2008 Jul;65(7):805-15
pubmed: 18606953
Biol Psychiatry. 2015 Jun 15;77(12):1061-70
pubmed: 25681871
Neuroscience. 2011 Sep 15;191:55-77
pubmed: 21439354
Horm Behav. 2016 Jan;77:113-23
pubmed: 26268151
Child Psychiatry Hum Dev. 2017 Apr;48(2):308-315
pubmed: 27100724
Front Cell Neurosci. 2014 Aug 11;8:222
pubmed: 25157218
Horm Behav. 2006 Sep;50(3):370-82
pubmed: 16780843
Psychopharmacology (Berl). 2006 Jun;186(3):425-33
pubmed: 16724188
Am J Obstet Gynecol. 2002 May;186(5):899-902
pubmed: 12015507
Compr Psychiatry. 2003 May-Jun;44(3):234-46
pubmed: 12764712
Genes Brain Behav. 2013 Oct;12(7):681-94
pubmed: 23941164
Annu Rev Clin Psychol. 2013;9:379-407
pubmed: 23394227
Psychol Med. 1999 May;29(3):645-54
pubmed: 10405086
Psychol Med. 1997 Mar;27(2):253-60
pubmed: 9089818
Psychopharmacology (Berl). 2014 Sep;231(17):3333-42
pubmed: 24402140
J Affect Disord. 2006 Apr;91(2-3):97-111
pubmed: 16466664
J Affect Disord. 1998 Jun;49(3):167-80
pubmed: 9629946
Eur Child Adolesc Psychiatry. 2003 Apr;12(2):75-83
pubmed: 12664271
PLoS One. 2014 Jun 03;9(6):e98839
pubmed: 24892749
Am J Psychiatry. 2000 Jun;157(6):924-30
pubmed: 10831472
Psychopharmacology (Berl). 2005 Dec;183(3):300-7
pubmed: 16228195
Psychoneuroendocrinology. 2013 Oct;38(10):1929-52
pubmed: 23608136
JAMA. 2002 Apr 10;287(14):1840-7
pubmed: 11939870
J Clin Endocrinol Metab. 2011 Jan;96(1):E40-7
pubmed: 20943787
Clin Obstet Gynecol. 2009 Sep;52(3):516-29
pubmed: 19661765
Arch Pediatr Adolesc Med. 1996 Jan;150(1):64-9
pubmed: 8542009
Psychol Med. 2014 Aug;44(11):2309-22
pubmed: 24495551
Neuropsychobiology. 1998 Nov;38(4):222-5
pubmed: 9813461
Neuropsychopharmacology. 2012 May;37(6):1422-32
pubmed: 22257897
Stress. 2011 Nov;14(6):677-84
pubmed: 21875305
Psychosom Med. 2011 Oct;73(8):656-63
pubmed: 21949424
Psychol Med. 1996 Jan;26(1):135-41
pubmed: 8643752
Neurotherapeutics. 2013 Oct;10(4):782-8
pubmed: 23963788
Am J Obstet Gynecol. 2000 May;182(5):1080-2
pubmed: 10819833
Br J Psychiatry. 2000 Dec;177:486-92
pubmed: 11102321
J Vis Exp. 2013 Jun 10;(76):e50324
pubmed: 23792810
CNS Spectr. 2015 Feb;20(1):48-59
pubmed: 25263255
Mol Psychiatry. 2011 Apr;16(4):383-406
pubmed: 21079608
Psychol Med. 2018 May;48(7):1190-1200
pubmed: 28950923
Psychoneuroendocrinology. 2007 Feb;32(2):133-9
pubmed: 17207585
Behav Neurol. 2015;2015:913843
pubmed: 26347585
Neuropsychopharmacology. 2012 Oct;37(11):2428-35
pubmed: 22805604
Am J Psychiatry. 2006 Sep;163(9):1549-53
pubmed: 16946179
Psychoneuroendocrinology. 2013 Feb;38(2):219-28
pubmed: 22770862
Obstet Gynecol. 2015 May;125(5):1268-1271
pubmed: 25932866
Cochrane Database Syst Rev. 2000;(2):CD001690
pubmed: 10796270
Behav Brain Res. 2018 Jan 15;336:236-243
pubmed: 28889022
Horm Behav. 2010 Nov;58(5):769-79
pubmed: 20688070
Br J Psychiatry. 1980 Apr;136:339-46
pubmed: 7388241
Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13042-13047
pubmed: 29158391
J Neuroendocrinol. 2011 Nov;23(11):1020-35
pubmed: 21815954
Eur J Neurosci. 1998 Sep;10(9):2905-12
pubmed: 9758160
Am J Reprod Immunol. 2012 Jun;67(6):506-14
pubmed: 22017458
Brain Res. 2014 Sep 11;1580:133-42
pubmed: 24184574
Am J Psychiatry. 2009 Nov;166(11):1229-37
pubmed: 19755578
Arch Womens Ment Health. 2016 Oct;19(5):799-808
pubmed: 26957508
Psychosomatics. 1998 Mar-Apr;39(2):93-101
pubmed: 9584534
Arch Womens Ment Health. 2011 Aug;14(4):355-9
pubmed: 21713456
Biol Res Nurs. 2010 Jul;12(1):73-83
pubmed: 20453020
Psychoneuroendocrinology. 2007 Jan;32(1):65-71
pubmed: 17118566
Mol Psychiatry. 2014 May;19(5):560-7
pubmed: 23689534
Neuron. 2008 Jul 31;59(2):207-13
pubmed: 18667149
Iran J Psychiatry Behav Sci. 2011 Fall;5(2):5-11
pubmed: 24644441
Am J Psychiatry. 2010 Nov;167(11):1373-80
pubmed: 20843875
J Psychiatr Res. 2012 Sep;46(9):1109-17
pubmed: 22721547
Neurosci Biobehav Rev. 2015 Sep;56:330-44
pubmed: 26234819
J Womens Health (Larchmt). 2008 Nov;17(9):1529-34
pubmed: 18710365
Front Neuroendocrinol. 2001 Apr;22(2):140-5
pubmed: 11259135
Neuropsychiatr Dis Treat. 2013;9:277-87
pubmed: 23459664
J Abnorm Psychol. 1990 Feb;99(1):3-15
pubmed: 2307763
Psychoneuroendocrinology. 2007 Apr;32(3):235-45
pubmed: 17346901
Depress Anxiety. 2007;24(7):495-517
pubmed: 17117412
Psychoneuroendocrinology. 2011 Jul;36(6):790-6
pubmed: 21106297
Brain Res. 1989 Mar 20;482(2):397-401
pubmed: 2539888
Arch Med Res. 2006 Jan;37(1):133-9
pubmed: 16314199
Curr Psychiatry Rep. 2017 Aug 19;19(10):70
pubmed: 28823105
Semin Reprod Endocrinol. 1997 Feb;15(1):77-89
pubmed: 9065980
Annu Rev Clin Psychol. 2015;11:99-137
pubmed: 25822344
JAMA Psychiatry. 2013 May;70(5):490-8
pubmed: 23487258
Neuropeptides. 2015 Aug;52:103-11
pubmed: 26049556
World J Psychiatry. 2015 Mar 22;5(1):103-11
pubmed: 25815259
Womens Health (Lond). 2012 Nov;8(6):659-72
pubmed: 23181531
Neuropsychopharmacology. 2018 Jun;43(7):1573-1580
pubmed: 29453442
Prog Neuropsychopharmacol Biol Psychiatry. 2004 May;28(3):435-51
pubmed: 15093950
Int J Neuropsychopharmacol. 2013 Aug;16(7):1513-28
pubmed: 23449091
Front Genet. 2015 Jul 21;6:243
pubmed: 26257770
J Abnorm Psychol. 1982 Dec;91(6):457-61
pubmed: 7153419
Physiol Behav. 2004 Dec 15;83(3):505-13
pubmed: 15581673
J Affect Disord. 2002 Aug;70(3):291-306
pubmed: 12128241
J Am Acad Child Adolesc Psychiatry. 2009 Sep;48(9):919-927
pubmed: 19625979
Psychoneuroendocrinology. 1999 Jan;24(1):69-84
pubmed: 10098220
Obstet Gynecol. 2005 Nov;106(5 Pt 1):1071-83
pubmed: 16260528
Soc Cogn Affect Neurosci. 2012 Feb;7(2):125-34
pubmed: 21208990
Psychoneuroendocrinology. 2017 May;79:116-121
pubmed: 28278440
Prog Neurobiol. 2014 Feb;113:79-87
pubmed: 24215796
J Reprod Med. 2003 Jun;48(6):402-8
pubmed: 12856509
J Affect Disord. 2012 Feb;136(3):1192-7
pubmed: 22209125
Gen Hosp Psychiatry. 2004 Jul-Aug;26(4):289-95
pubmed: 15234824
Arch Gen Psychiatry. 2009 Feb;66(2):162-9
pubmed: 19188538
Br J Psychiatry. 1993 Jul;163:27-31
pubmed: 8353695
J Affect Disord. 2006 Jan;90(1):49-55
pubmed: 16337009
Biol Res Nurs. 2007 Jan;8(3):210-22
pubmed: 17172320
PLoS One. 2008 Apr 09;3(4):e1974
pubmed: 18398484
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13284-9
pubmed: 9789080
J Child Psychol Psychiatry. 1992 Mar;33(3):543-61
pubmed: 1577898
Mol Psychiatry. 2012 Feb;17(2):119-21
pubmed: 21912392
J Affect Disord. 2010 Sep;125(1-3):128-33
pubmed: 20051292
Neural Plast. 2015;2015:170435
pubmed: 26413323
Obstet Gynecol. 2001 Jan;97(1):77-80
pubmed: 11152912
Nat Neurosci. 2008 Sep;11(9):1001-3
pubmed: 19160496
Biol Psychiatry. 2011 Aug 15;70(4):395-9
pubmed: 21507385
Am J Psychiatry. 1998 Jul;155(7):910-3
pubmed: 9659856
Arch Womens Ment Health. 2005 Jun;8(2):77-87
pubmed: 15883651
J Affect Disord. 2009 May;115(1-2):287-92
pubmed: 18708264
Trends Neurosci. 2017 Feb;40(2):106-120
pubmed: 28129895
Expert Opin Pharmacother. 2009 Nov;10(16):2593-607
pubmed: 19874247
Soc Neurosci. 2016 Dec;11(6):600-17
pubmed: 26680151
Br J Psychiatry. 2008 Nov;193(5):383-8
pubmed: 18978318
Pediatrics. 2009 Apr;123(4):e736-51
pubmed: 19336362
Braz J Psychiatry. 2014 Jan-Mar;36(1):96-7
pubmed: 24604465
Front Neural Circuits. 2013 Sep 17;7:144
pubmed: 24062647
Can J Psychiatry. 2012 Nov;57(11):704-12
pubmed: 23149286
Neurosci Lett. 2018 Feb 5;665:48-53
pubmed: 29174640
Trends Neurosci. 2008 Sep;31(9):464-8
pubmed: 18675469
Neuron. 2018 Apr 4;98(1):192-207.e10
pubmed: 29621487
Arch Gen Psychiatry. 1986 Jun;43(6):569-73
pubmed: 3707289
J Neurosci. 2004 Apr 28;24(17):4113-23
pubmed: 15115806
J Clin Psychiatry. 2001 May;62(5):332-6
pubmed: 11411813
Lancet. 1996 Apr 6;347(9006):930-3
pubmed: 8598756
Sci Rep. 2016 Feb 24;6:21825
pubmed: 26906716
Pharmacol Biochem Behav. 2007 Oct;87(4):412-9
pubmed: 17597197
J Abnorm Psychol. 1984 May;93(2):158-71
pubmed: 6725749
Neural Plast. 2016;2016:2762518
pubmed: 26819762
PLoS One. 2013 Apr 18;8(4):e61443
pubmed: 23637833
Lancet. 2017 Jul 29;390(10093):480-489
pubmed: 28619476