Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue.
Animals
Antineoplastic Agents
/ chemistry
Brain
/ drug effects
Brain Neoplasms
/ drug therapy
Cell Line, Tumor
Drug Carriers
/ chemistry
Drug Delivery Systems
/ methods
Glioma
/ drug therapy
Lactic Acid
/ chemistry
Male
Mice
Mice, Inbred BALB C
Nanoparticles
/ chemistry
Paclitaxel
/ chemistry
Polyethylene Glycols
/ chemistry
Polyglycolic Acid
/ chemistry
Rats
Tissue Distribution
Vitamin E
/ chemistry
blood-brain barrier
brain tumor
drug delivery
nanoparticles
surface coating
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
09
10
2018
revised:
01
12
2018
accepted:
04
12
2018
pubmed:
16
12
2018
medline:
25
6
2020
entrez:
16
12
2018
Statut:
ppublish
Résumé
Surface-modified poly(d,l-lactic-co-glycolic acid) PLGA nanoparticles (NPs) were fabricated via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain tumor. The cellular uptake and cytotoxicity of NPs were evaluated on C6 glioma cells in vitro, and BALB/c mice were used to study the brain penetration and biodistribution upon intravenous administration. Results showed that by finely tuning nanoprecipitation parameters, PLGA NPs coated with surfactants with a size around 150 nm could provide a sustained release of PTX for >2 weeks. Surface coatings could increase cellular uptake efficiency when compared with noncoated NPs, and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) showed the most significant enhancement. The in vivo evaluation of TPGS-PLGA NPs showed amplified accumulation (>800% after 96 h) of PTX in the brain tissue when compared with bare NPs and Taxol
Identifiants
pubmed: 30552956
pii: S0022-3549(18)30797-4
doi: 10.1016/j.xphs.2018.12.002
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Carriers
0
Vitamin E
1406-18-4
Polyglycolic Acid
26009-03-0
Lactic Acid
33X04XA5AT
Polyethylene Glycols
3WJQ0SDW1A
Paclitaxel
P88XT4IS4D
polyethylene glycol 1000
U076Q6Q621
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1736-1745Informations de copyright
Copyright © 2019 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.