Cranberry juice decreases disease activity in women with rheumatoid arthritis.
Adult
Aged
Anti-Citrullinated Protein Antibodies
/ blood
Anti-Inflammatory Agents
/ administration & dosage
Antioxidants
/ administration & dosage
Arthritis, Rheumatoid
/ blood
Biomarkers
/ blood
Female
Fruit and Vegetable Juices
/ analysis
Humans
Middle Aged
Prospective Studies
Severity of Illness Index
Vaccinium macrocarpon
Bioactive compounds
Cranberry
Inflammation
Polyphenols
Rheumatoid arthritis
Journal
Nutrition (Burbank, Los Angeles County, Calif.)
ISSN: 1873-1244
Titre abrégé: Nutrition
Pays: United States
ID NLM: 8802712
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
15
05
2018
revised:
14
09
2018
accepted:
07
10
2018
pubmed:
16
12
2018
medline:
26
3
2020
entrez:
16
12
2018
Statut:
ppublish
Résumé
Studies have shown that cranberry (Vaccinium macrocarpon) has antiinflammatory and antioxidant effects; however, to our knowledge, the effects of cranberry juice consumption have not been studied in patients with rheumatoid arthritis (RA). The aim of this study was to verify the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA. A prospective study was conducted with 41 women diagnosed with RA. The disease activity measured by Disease Activity Score 28 (DAS28) and anticyclic citrullinated peptide (anti-CCP) antibodies, and several inflammatory and biochemical biomarkers were analyzed. The control group (n = 18) maintained their usual diet. The cranberry group (n = 23) consumed 500 mL/d of low-calorie cranberry juice. Regarding the baseline values, the cranberry group presented a decrease in the values of DAS28 (P = 0.048) and anti-CCP (P = 0.034) after 90 d of treatment, whereas changes in inflammatory biomarkers were not found. The present study indicated that cranberry juice decreases disease activity and therefore has beneficial effects for RA patients, although larger and long-term studies are needed to definitively probe this effect and to clarify the mechanisms involved.
Identifiants
pubmed: 30553231
pii: S0899-9007(18)30380-0
doi: 10.1016/j.nut.2018.10.010
pii:
doi:
Substances chimiques
Anti-Citrullinated Protein Antibodies
0
Anti-Inflammatory Agents
0
Antioxidants
0
Biomarkers
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-117Informations de copyright
Copyright © 2019. Published by Elsevier Inc.