Frequency of superantigen encoding genes of Staphylococcus aureus isolates collected from multiple sclerosis (MS) patients and nasal carriers.
Adult
Anti-Bacterial Agents
/ pharmacology
Carrier State
/ microbiology
Drug Resistance, Bacterial
Enterotoxins
/ genetics
Exfoliatins
/ genetics
Female
Humans
Male
Middle Aged
Multiple Sclerosis
/ complications
Nasal Mucosa
/ microbiology
Staphylococcal Infections
/ microbiology
Staphylococcus aureus
/ drug effects
Superantigens
/ genetics
Young Adult
Multiple sclerosis
Staphylococcus aureus
Super antigens
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
26
04
2018
revised:
05
12
2018
accepted:
06
12
2018
pubmed:
17
12
2018
medline:
15
3
2019
entrez:
17
12
2018
Statut:
ppublish
Résumé
Bacterial superantigens are potent T cell activators that can have acute or chronic effects on the central nervous system. In this study, the role of enterotoxins, exfoliative toxins and toxic shock syndrome toxin of Staphylococcus aureus was investigated in MS patients and healthy nasal carriers. Three-hundred fifty nasal swabs were collected from healthy nasal carriers (n = 210) and MS (n = 140) patients. Staphylococcus aureus superantigens were detected by multiplex PCR. Antimicrobial susceptibility pattern was performed using disk diffusion method. The highest rates of nasal colonization were seen in MS patients (46.42%). The rates of nasal colonization in the healthcare workers were 30.95%. The most commonly detected superantigens were SEA (31.5%), SEB (17.7%) and ETA (16.9%). The Staphylococcus aureus isolates had the highest levels of resistance against erythromycin (57.7%), clindamycin (55.4%) and co-trimoxazole (43.1%). All isolates were susceptible to vancomycin, linezolid, and mupirocin. Our results revealed that the frequency of superantigen producing Staphylococcus aureus isolates is high in the MS patients. As well as these isolates are sensitive to mupirocin. Thus it is better to use of mupirocin for nasal decolonization of Staphylococcus aureus in the MS patients.
Sections du résumé
BACKGROUND
BACKGROUND
Bacterial superantigens are potent T cell activators that can have acute or chronic effects on the central nervous system.
OBJECTIVES
OBJECTIVE
In this study, the role of enterotoxins, exfoliative toxins and toxic shock syndrome toxin of Staphylococcus aureus was investigated in MS patients and healthy nasal carriers.
METHODS
METHODS
Three-hundred fifty nasal swabs were collected from healthy nasal carriers (n = 210) and MS (n = 140) patients. Staphylococcus aureus superantigens were detected by multiplex PCR. Antimicrobial susceptibility pattern was performed using disk diffusion method.
RESULTS
RESULTS
The highest rates of nasal colonization were seen in MS patients (46.42%). The rates of nasal colonization in the healthcare workers were 30.95%. The most commonly detected superantigens were SEA (31.5%), SEB (17.7%) and ETA (16.9%). The Staphylococcus aureus isolates had the highest levels of resistance against erythromycin (57.7%), clindamycin (55.4%) and co-trimoxazole (43.1%). All isolates were susceptible to vancomycin, linezolid, and mupirocin.
CONCLUSION
CONCLUSIONS
Our results revealed that the frequency of superantigen producing Staphylococcus aureus isolates is high in the MS patients. As well as these isolates are sensitive to mupirocin. Thus it is better to use of mupirocin for nasal decolonization of Staphylococcus aureus in the MS patients.
Identifiants
pubmed: 30553909
pii: S0882-4010(18)30739-3
doi: 10.1016/j.micpath.2018.12.010
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Enterotoxins
0
Exfoliatins
0
Superantigens
0
toxic shock syndrome toxin 2, Staphylococcus aureus
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
316-319Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.