Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance.

Adaptation, Physiological Animals Disease Progression Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition Humans Neoplasms / drug therapy Neoplastic Stem Cells / drug effects
cancer epithelial to mesenchymal transition plasticity therapy resistance

Journal

Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472

Informations de publication

Date de publication:
03 01 2019
Historique:
pubmed: 18 12 2018
medline: 4 3 2020
entrez: 18 12 2018
Statut: ppublish

Résumé

Our traditional understanding of phenotypic plasticity in adult somatic cells comprises dedifferentiation and transdifferentiation in the context of tissue regeneration or wound healing. Although dedifferentiation is central to tissue repair and stemness, this process inherently carries the risk of cancer initiation. Consequently, recent research suggests phenotypic plasticity as a new paradigm for understanding cancer initiation, progression, and resistance to therapy. Here, we discuss how cells acquire plasticity and the role of plasticity in initiating cancer, cancer progression, and metastasis and in developing therapy resistance. We also highlight the epithelial-to-mesenchymal transition (EMT) and known molecular mechanisms underlying plasticity and we consider potential therapeutic avenues.

Identifiants

DOI: 10.1016/j.stem.2018.11.011 PMID: 30554963 PMC: PMC7297507
pubmed: 30554963
pii: S1934-5909(18)30547-2
doi: 10.1016/j.stem.2018.11.011
pmc: PMC7297507
mid: NIHMS1035668
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

65-78

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM124491
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD073035
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Références

Cell. 1982 Aug;30(1):215-24
pubmed: 7127471
Genes Dev. 2010 Jun 1;24(11):1106-18
pubmed: 20516196
Clin Cancer Res. 2015 Feb 15;21(4):899-906
pubmed: 25516888
Nat Cell Biol. 2017 May;19(5):518-529
pubmed: 28414315
Nat Commun. 2017 Aug 4;8(1):196
pubmed: 28775303
Mol Oncol. 2011 Feb;5(1):5-23
pubmed: 21147047
Cancer Cell. 2012 Feb 14;21(2):253-65
pubmed: 22340597
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7838-43
pubmed: 21521790
Breast Cancer Res. 2008;10(3):R53
pubmed: 18559090
Cell. 2008 May 16;133(4):704-15
pubmed: 18485877
Oncogene. 2002 May 9;21(20):3241-6
pubmed: 12082640
Cell Rep. 2016 Oct 25;17(5):1302-1317
pubmed: 27783945
Nat Genet. 2005 Oct;37(10):1047-54
pubmed: 16142232
Cancer Res. 1996 Jan 15;56(2):402-4
pubmed: 8542598
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4153-4158
pubmed: 28377514
Cancer Res. 2009 Jul 1;69(13):5312-20
pubmed: 19549918
Cell. 2017 Feb 9;168(4):670-691
pubmed: 28187288
Cancer Res. 2011 Jan 1;71(1):245-54
pubmed: 21199805
Nature. 2011 Jan 20;469(7330):314-22
pubmed: 21248838
Nature. 2010 Nov 25;468(7323):521-6
pubmed: 21057492
Front Oncol. 2015 Jul 20;5:155
pubmed: 26258068
Acta Anat (Basel). 1995;152(3):195-204
pubmed: 7572029
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
PLoS One. 2014 Jan 29;9(1):e87409
pubmed: 24489910
J Biol Chem. 2009 May 15;284(20):13355-62
pubmed: 19324877
Wilhelm Roux Arch Entwickl Mech Org. 1928 Oct;114(1):108-143
pubmed: 28354258
Cell. 2009 Aug 21;138(4):645-659
pubmed: 19682730
J Cell Physiol. 2005 Mar;202(3):858-66
pubmed: 15389643
Nat Commun. 2016 Feb 15;7:10498
pubmed: 26876920
Stem Cell Reports. 2014 Apr 24;2(5):633-47
pubmed: 24936451
J Natl Cancer Inst. 2008 May 7;100(9):672-9
pubmed: 18445819
Cell. 2011 Nov 11;147(4):759-72
pubmed: 22078877
Breast Cancer Res. 2016 Mar 01;18(1):19
pubmed: 26926363
Nature. 2012 Jul 26;487(7408):496-9
pubmed: 22763436
Integr Biol (Camb). 2010 Sep;2(9):424-34
pubmed: 20717570
Dev Cell. 2008 Apr;14(4):570-81
pubmed: 18410732
Int J Cancer. 2013 Apr 1;132(7):1487-95
pubmed: 22833228
Int J Cancer. 2015 Dec 1;137(11):2566-77
pubmed: 26077342
Cell. 2012 Jul 6;150(1):136-50
pubmed: 22770217
Nat Rev Mol Cell Biol. 2006 Feb;7(2):131-42
pubmed: 16493418
Cell. 1987 Dec 24;51(6):987-1000
pubmed: 3690668
Pigment Cell Melanoma Res. 2014 Mar;27(2):162-8
pubmed: 24330305
Nature. 2015 Nov 26;527(7579):525-530
pubmed: 26560028
Cell Tissue Res. 2007 Jul;329(1):129-36
pubmed: 17440749
J Clin Pathol. 2006 Oct;59(10):1079-83
pubmed: 16467167
Trends Cancer. 2015 Sep;1(1):44-52
pubmed: 28741562
Hum Mol Genet. 2009 Aug 15;18(16):3098-109
pubmed: 19477956
Cell Stem Cell. 2010 Sep 3;7(3):403-17
pubmed: 20804975
Oncotarget. 2016 May 10;7(19):27067-84
pubmed: 27008704
Nat Rev Cancer. 2018 Feb;18(2):128-134
pubmed: 29326430
Curr Top Dev Biol. 1980;16:349-80
pubmed: 7009071
Nat Med. 2009 Aug;15(8):907-13
pubmed: 19648928
Cancer Sci. 2016 Aug;107(8):1079-91
pubmed: 27234159
Nat Cell Biol. 2011 Mar;13(3):215-22
pubmed: 21278734
Nat Cell Biol. 2009 Dec;11(12):1487-95
pubmed: 19935649
Nature. 2011 Oct 09;479(7372):189-93
pubmed: 21983963
Anat Rec. 1947 Dec;99(4):568
pubmed: 18895366
Proc Natl Acad Sci U S A. 1968 Sep;61(1):53-60
pubmed: 4301594
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7950-5
pubmed: 21498687
Cancer Discov. 2014 Jun;4(6):702-15
pubmed: 24705811
Nature. 1999 Apr 22;398(6729):714-8
pubmed: 10227294
PLoS One. 2012;7(12):e53498
pubmed: 23300933
Cell. 2010 Aug 6;142(3):375-86
pubmed: 20691899
Nat Commun. 2017 Oct 20;8(1):1079
pubmed: 29057869
Clin Chem. 2013 Jan;59(1):168-79
pubmed: 23220226
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6470-6475
pubmed: 29866841
Clin Exp Metastasis. 2000;18(7):553-60
pubmed: 11688960
PLoS One. 2008 Aug 06;3(8):e2888
pubmed: 18682804
Oncogene. 2016 Mar 3;35(9):1111-21
pubmed: 25982283
Cell Stem Cell. 2015 Jan 8;16(1):67-79
pubmed: 25575080
Breast Cancer Res. 2009;11(4):R46
pubmed: 19589136
Nature. 2015 Nov 26;527(7579):472-6
pubmed: 26560033
Dev Biol. 1983 Jun;97(2):274-90
pubmed: 6852366
Nature. 2018 Apr;556(7702):463-468
pubmed: 29670281
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2772-7
pubmed: 21940501
Oncotarget. 2016 Apr 26;7(17):24677-87
pubmed: 27013581
Circ Res. 2009 Mar 27;104(6):733-41
pubmed: 19197075
Science. 2013 Feb 1;339(6119):580-4
pubmed: 23372014
Cell Stem Cell. 2011 Feb 4;8(2):149-63
pubmed: 21295272
Lab Invest. 2012 May;92(5):744-52
pubmed: 22349639
PLoS Biol. 2014 Sep 09;12(9):e1001945
pubmed: 25203443
Cell Rep. 2014 Mar 27;6(6):1059-1072
pubmed: 24613358
Nature. 2001 Nov 1;414(6859):105-11
pubmed: 11689955
Mol Cell Biol. 2008 Apr;28(7):2426-36
pubmed: 18227151
Nat Cell Biol. 2013 May;15(5):451-60
pubmed: 23604318
Cell. 2011 Aug 19;146(4):633-44
pubmed: 21854987
Cancer Res. 2016 Nov 15;76(22):6520-6532
pubmed: 27651311
Nat Cell Biol. 2009 Dec;11(12):1444-50
pubmed: 19935651
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Nature. 2013 Nov 14;503(7475):218-23
pubmed: 24196716
EMBO Mol Med. 2012 May;4(5):353-61
pubmed: 22383126
Cell. 2012 Mar 2;148(5):1015-28
pubmed: 22385965
Nature. 2008 Oct 2;455(7213):627-32
pubmed: 18754011
Oncotarget. 2017 Feb 7;8(6):9293-9302
pubmed: 28030836
Nature. 2015 Sep 3;525(7567):119-23
pubmed: 26266985
Cell. 2013 Jan 17;152(1-2):25-38
pubmed: 23273993
BMC Cancer. 2012 Nov 14;12:521
pubmed: 23151184
Nat Rev Cancer. 2009 Apr;9(4):265-73
pubmed: 19262571
Cell. 2016 Jun 30;166(1):21-45
pubmed: 27368099
PLoS One. 2015 Apr 24;10(4):e0123976
pubmed: 25909322
Cancer Cell. 2007 Aug;12(2):160-70
pubmed: 17692807
Nature. 2010 Feb 25;463(7284):1035-41
pubmed: 20107439
Br J Cancer. 2011 Oct 25;105(9):1338-41
pubmed: 21970878
Cell Stem Cell. 2017 Feb 2;20(2):191-204.e5
pubmed: 27889319
Mol Reprod Dev. 2010 Oct;77(10):837-55
pubmed: 20602493
Dev Biol. 2012 Dec 1;372(1):28-44
pubmed: 23000969
Oncogene. 2008 Aug 7;27(34):4690-701
pubmed: 18408755

Auteurs

Piyush B Gupta (PB)

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: piyush@mit.edu.

Ievgenia Pastushenko (I)

Université Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium.

Adam Skibinski (A)

Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA; Raymond and Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA; Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington St., Boston, MA 02111, USA.

Cedric Blanpain (C)

Université Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium; WELBIO, Université Libre de Bruxelles, Brussels 1070, Belgium. Electronic address: cedric.blanpain@ulb.ac.be.

Charlotte Kuperwasser (C)

Université Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA; Raymond and Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA. Electronic address: charlotte.kuperwasser@tufts.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Phenotypic Plasticity: Driver of Cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Phenotypic Plasticity: Driver of Cancer...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Phenotypic Plasticity: Driver of Cancer...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Phenotypic Plasticity: Driver of Cancer...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › Phenotypic Plasticity: Driver of Cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Phenotypic Plasticity: Driver of Cancer...
questionsmedicales.fr › Tumeurs › Phenotypic Plasticity: Driver of Cancer...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › Phenotypic Plasticity: Driver of Cancer...