Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor.
Antiviral Agents
/ chemical synthesis
Catalytic Domain
Coronavirus 3C Proteases
Cysteine Endopeptidases
/ chemistry
Cysteine Proteinase Inhibitors
/ chemical synthesis
Isoquinolines
/ chemical synthesis
Molecular Docking Simulation
Molecular Structure
Severe acute respiratory syndrome-related coronavirus
/ enzymology
Viral Proteins
/ antagonists & inhibitors
Decahydroisoquinolin
Inhibitor
Non-prime site
SARS 3CL protease
Thioacetal
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
12
11
2018
revised:
10
12
2018
accepted:
11
12
2018
pubmed:
19
12
2018
medline:
17
9
2019
entrez:
19
12
2018
Statut:
ppublish
Résumé
A non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold was evaluated as a novel inhibitor for severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL
Identifiants
pubmed: 30558861
pii: S0968-0896(18)31916-3
doi: 10.1016/j.bmc.2018.12.019
pmc: PMC7126642
pii:
doi:
Substances chimiques
Antiviral Agents
0
Cysteine Proteinase Inhibitors
0
Isoquinolines
0
Viral Proteins
0
Cysteine Endopeptidases
EC 3.4.22.-
Coronavirus 3C Proteases
EC 3.4.22.28
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
425-435Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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