Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
24
08
2018
accepted:
09
11
2018
entrez:
19
12
2018
pubmed:
19
12
2018
medline:
22
5
2019
Statut:
ppublish
Résumé
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in Alzheimer's disease. However, the underlying neuronal mechanisms are unknown. By employing in vivo two-photon Ca
Identifiants
pubmed: 30559471
doi: 10.1038/s41593-018-0289-8
pii: 10.1038/s41593-018-0289-8
pmc: PMC6560629
mid: NIHMS1025207
doi:
Substances chimiques
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-64Subventions
Organisme : NIA NIH HHS
ID : P30 AG062421
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005134
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058674
Pays : United States
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