Intermediate cell states in epithelial-to-mesenchymal transition.
Journal
Physical biology
ISSN: 1478-3975
Titre abrégé: Phys Biol
Pays: England
ID NLM: 101197454
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
pubmed:
19
12
2018
medline:
26
2
2019
entrez:
19
12
2018
Statut:
epublish
Résumé
The transition of epithelial cells into a mesenchymal state (epithelial-to-mesenchymal transition or EMT) is a highly dynamic process implicated in various biological processes. During EMT, cells do not necessarily exist in 'pure' epithelial or mesenchymal states. There are cells with mixed (or hybrid) features of the two, which are termed as the intermediate cell states (ICSs). While the exact functions of ICS remain elusive, together with EMT it appears to play important roles in embryogenesis, tissue development, and pathological processes such as cancer metastasis. Recent single cell experiments and advanced mathematical modeling have improved our capability in identifying ICS and provided a better understanding of ICS in development and disease. Here, we review the recent findings related to the ICS in/or EMT and highlight the challenges in the identification and functional characterization of ICS.
Identifiants
pubmed: 30560804
doi: 10.1088/1478-3975/aaf928
pmc: PMC6602058
mid: NIHMS1034880
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
021001Subventions
Organisme : NIAMS NIH HHS
ID : R56 AR064532
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR068074
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123731
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR073159
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR075047
Pays : United States
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