Effect of chemotherapy and aromatase inhibitors in the adjuvant treatment of breast cancer on glucose and insulin metabolism-A systematic review.
breast cancer
chemotherapy
glucose
insulin
weight gain
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
27
09
2018
revised:
14
11
2018
accepted:
20
11
2018
pubmed:
19
12
2018
medline:
4
3
2020
entrez:
19
12
2018
Statut:
ppublish
Résumé
Breast cancer (BC) is the most common cancer among women worldwide. With increasing survival rates, focus has expanded to long-term adverse effects of adjuvant chemotherapy and/or aromatase inhibitors. Weight gain during chemotherapy has been well documented, but the underlying mechanisms remain unclear. A change in glucose and insulin metabolism is a possible consequence. We searched PubMed on the 4th of May 2018, and found eight articles that compared measurements of glucose and insulin before and after chemotherapy and/or aromatase inhibitors in woman with BC. A general trend of increased glucose and insulin is seen and likely to be caused by weight gain and/or changes in body composition as a consequence of adjuvant treatment of BC. Due to methodological limitations including short follow-up times and small sample sizes, further studies are required to better describe metabolic consequences of adjuvant chemotherapy and/or aromatase inhibitors. Future studies could help identify patients in high-risk of developing cardiometabolic disease after BC treatment.
Identifiants
pubmed: 30561133
doi: 10.1002/cam4.1911
pmc: PMC6346263
doi:
Substances chimiques
Antineoplastic Agents
0
Aromatase Inhibitors
0
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
238-245Informations de copyright
© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
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