PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Cell Proliferation
/ drug effects
Female
Humans
Hypoglycemic Agents
/ administration & dosage
Insulin
/ metabolism
Metformin
/ administration & dosage
Middle Aged
Neoplasm Staging
Phosphatidylinositol 3-Kinases
/ metabolism
Preoperative Care
Prognosis
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
TOR Serine-Threonine Kinases
/ metabolism
Treatment Outcome
Uterine Neoplasms
/ diagnosis
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
11
10
2018
revised:
27
11
2018
accepted:
13
12
2018
pubmed:
20
12
2018
medline:
30
5
2020
entrez:
20
12
2018
Statut:
ppublish
Résumé
Endometrioid endometrial cancer is strongly associated with obesity and insulin resistance. Metformin, an insulin sensitizer, reduces endometrial tumor growth Eighty-eight women received metformin ( Short-term treatment with standard diabetic doses of metformin does not reduce tumor proliferation in women with endometrioid endometrial cancer awaiting hysterectomy. This study does not support a biological effect of metformin in endometrial cancer and casts doubt on its potential application in the primary and adjuvant treatment settings.
Identifiants
pubmed: 30563932
pii: 1078-0432.CCR-18-3339
doi: 10.1158/1078-0432.CCR-18-3339
pmc: PMC6586555
mid: EMS83349
doi:
Substances chimiques
Biomarkers, Tumor
0
Hypoglycemic Agents
0
Insulin
0
Metformin
9100L32L2N
MTOR protein, human
EC 2.7.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Clinical Trial, Phase III
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2424-2432Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR-CS-012-009
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098670/Z/12/Z
Pays : United Kingdom
Informations de copyright
©2018 American Association for Cancer Research.
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