Cancer-associated fibroblasts promote the stemness of CD24
Cancer stem cell
Cancer-associated fibroblasts
Hepatocellular carcinoma
Hepatocyte growth factor
Interleukin-6
STAT3
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
28
05
2018
accepted:
07
12
2018
revised:
12
11
2018
pubmed:
20
12
2018
medline:
28
5
2020
entrez:
20
12
2018
Statut:
ppublish
Résumé
Cancer stem cells (CSCs), which support tumor progress in hepatocellular carcinoma (HCC) developed in fibrotic or cirrhotic livers, are regulated by the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the major component of the tumor stroma in HCC; however, the mechanisms by which CAFs contribute to stemness maintenance remain largely unknown. Here, we found that the expression of CD24 was high in HCC tissues compared with adjacent normal liver tissues, and positively correlated with the poor prognosis and α-SMA expression in CAFs. CD24
Identifiants
pubmed: 30564864
doi: 10.1007/s00109-018-1731-9
pii: 10.1007/s00109-018-1731-9
doi:
Substances chimiques
CD24 Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
243-255Références
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