Non-motor Comorbidity of Myasthenia Gravis: Myasthenia Gravis as a Systemic Immunological Disorder Involving Non-motor Systems.
Agammaglobulinemia
/ complications
Alopecia
/ complications
Autoimmunity
/ physiology
Female
Humans
Middle Aged
Myasthenia Gravis
/ complications
Red-Cell Aplasia, Pure
/ complications
T-Lymphocytes
/ immunology
Thrombocytopenia
/ complications
Thymoma
/ complications
Thymus Neoplasms
/ complications
alopecia
myasthenia gravis
pure red cell aplasia
thymoma
thymoma-associated multiorgan autoimmunity
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 May 2019
01 May 2019
Historique:
pubmed:
21
12
2018
medline:
10
7
2019
entrez:
21
12
2018
Statut:
ppublish
Résumé
To explore non-motor comorbidities of myasthenia gravis (MG), we present two cases of thymoma-associated MG patients. Alopecia, pure red cell aplasia, and thymoma- associated multiorgan autoimmunity were observed in Case 1, and alopecia, thrombocytopenia, hypogammaglobulinemia and nephrotic syndrome were observed in Case 2. In both cases, autoreactive T lymphocytes inappropriately stimulated by thymus tissue may have played key roles in generating the various autoimmune-associated symptoms. Consequently, systemic immunological involvement due to the thymoma-associated breakdown of immunoregulations in both motor and non-motor systems should be considered in MG patients.
Identifiants
pubmed: 30568129
doi: 10.2169/internalmedicine.1990-18
pmc: PMC6543207
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1341-1347Références
Nihon Jinzo Gakkai Shi. 1999 Apr;41(2):77-82
pubmed: 10361423
Pathol Res Pract. 1999;195(8):535-40
pubmed: 10483583
Intern Med. 2000 Jun;39(6):490-4
pubmed: 10852171
Nihon Jinzo Gakkai Shi. 2000 Jul;42(5):394-8
pubmed: 10998921
Clin Neurol Neurosurg. 2003 Dec;106(1):16-8
pubmed: 14643910
Nihon Rinsho Meneki Gakkai Kaishi. 2006 Apr;29(2):102-6
pubmed: 16651708
J Am Acad Dermatol. 2007 Oct;57(4):683-9
pubmed: 17433850
Lancet Neurol. 2009 May;8(5):475-90
pubmed: 19375665
J Neurol Neurosurg Psychiatry. 2010 Aug;81(8):850-7
pubmed: 20547629
Eur J Neurol. 2013 Jan;20(1):205-7
pubmed: 22469332
J Neurol Neurosurg Psychiatry. 2013 Sep;84(9):989-94
pubmed: 23175856
Brain Nerve. 2013 Apr;65(4):477-83
pubmed: 23568996
Indian J Nephrol. 2013 Jan;23(1):75-6
pubmed: 23580814
Eur J Neurol. 2014 Feb;21(2):223-30
pubmed: 23829303
Rinsho Shinkeigaku. 2014;54(9):703-8
pubmed: 25283823
Clin Kidney J. 2012 Dec;5(6):562-5
pubmed: 26069802
J Cutan Pathol. 2015 Oct;42(10):663-8
pubmed: 26509934
Rinsho Shinkeigaku. 2017 May 27;57(5):208-213
pubmed: 28450687
Am J Gastroenterol. 1985 Nov;80(11):877-81
pubmed: 2996329
Ann Intern Med. 1966 Sep;65(3):554-9
pubmed: 5330146
J Clin Pathol. 1994 Jul;47(7):676-9
pubmed: 8089232
Kyobu Geka. 1993 Dec;46(13):1161-5
pubmed: 8258927
Neurology. 1997 Mar;48(3):774-5
pubmed: 9065564
J Dermatol. 1997 Dec;24(12):769-72
pubmed: 9492440