Distinct roles of brain activity and somatotopic representation in pathophysiology of focal dystonia.
brain activity
focal task-specific dystonia
functional magnetic resonance imaging
movement disorders
somatotopy
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
11
09
2018
revised:
25
10
2018
accepted:
21
11
2018
pubmed:
21
12
2018
medline:
9
4
2020
entrez:
21
12
2018
Statut:
ppublish
Résumé
Two main neural mechanisms including loss of cortical inhibition and maladaptive plasticity have been thought to be involved in the pathophysiology of focal task-specific dystonia. Such loss of inhibition and maladaptive plasticity likely correspond to cortical overactivity and disorganized somatotopy, respectively. However, the most plausible mechanism of focal task-specific dystonia remains unclear. To address this question, we assessed brain activity and somatotopic representations of motor-related brain areas using functional MRI and behavioral measurement in healthy instrumentalists and patients with embouchure dystonia as an example of focal task-specific dystonia. Dystonic symptoms were measured as variability of fundamental frequency during long tone playing. We found no significant differences in brain activity between the embouchure dystonia and healthy wind instrumentalists in the motor-related areas. Assessment of somatotopy, however, revealed significant differences in the somatotopic representations of the mouth area for the right somatosensory cortex between the two groups. Multiple-regression analysis revealed brain activity in the primary motor and somatosensory cortices, cerebellum, and putamen was significantly associated with variability of fundamental frequency signals representing dystonic symptoms. Conversely, somatotopic representations in motor-related brain areas were not associated with variability of fundamental frequency signals in embouchure dystonia. The present findings suggest that abnormal motor-related network activity and aberrant somatotopy correlate with different aspects of mechanisms underlying focal task-specific dystonia.
Identifiants
pubmed: 30570801
doi: 10.1002/hbm.24486
pmc: PMC6865568
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1738-1749Subventions
Organisme : JSPS KAKENHI
ID : 15H05357
Pays : International
Organisme : National Center of Neurology and Psychiatry
Pays : International
Organisme : AMED, KAKENHI
ID : 16H03306
Pays : International
Organisme : AMED, KAKENHI
ID : 18H04960
Pays : International
Organisme : AMED, KAKENHI
ID : 26120008
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 26-119
Pays : International
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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