Long-Term Burden of Higher Body Mass Index and Adult Arterial Stiffness Are Linked Predominantly Through Elevated Blood Pressure.
Adult
Blood Pressure
/ physiology
Blood Pressure Determination
/ methods
Body Mass Index
Cardiovascular Diseases
/ epidemiology
Child
Disease Progression
Female
Humans
Hypertension
/ diagnosis
Longitudinal Studies
Male
Middle Aged
Obesity
/ diagnosis
Pulse Wave Analysis
/ methods
Risk Factors
Time
United States
Vascular Stiffness
arterial stiffness
blood pressure
body mass index
hypertension
longitudinal studies
Journal
Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
entrez:
21
12
2018
pubmed:
21
12
2018
medline:
14
11
2019
Statut:
ppublish
Résumé
Obesity and hypertension are important risk factors of arterial stiffness. However, the complex relationship between increased body mass index (BMI), elevated blood pressure (BP), and arterial stiffness is largely unknown. We aim to examine the mediation effect of elevated BP on the association of early life BMI, long-term burden, and trend of BMI with arterial stiffness in midlife. The longitudinal study cohort consisted of 1190 participants (829 whites and 361 blacks, 518 males, mean age=40.0 years at follow-up) who had been examined for BMI and BP 4 to 15 times from childhood and aortic-femoral pulse wave velocity (afPWV) in adulthood, with a mean follow-up period of 30.3 years. Total area under the curve (AUC
Identifiants
pubmed: 30571556
doi: 10.1161/HYPERTENSIONAHA.118.12106
pmc: PMC6310035
mid: NIHMS1511856
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
229-234Subventions
Organisme : NIA NIH HHS
ID : R03 AG060619
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL121230
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG016592
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009107
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM109036
Pays : United States
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