Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule.

Adrenergic beta-Agonists / pharmacology Adrenergic beta-Antagonists / pharmacology Animals Ion Transport / drug effects Isoproterenol / pharmacology Kidney Tubules, Distal / drug effects Mice Mice, Knockout Norepinephrine / metabolism Potassium Channels, Inwardly Rectifying / metabolism Propranolol / pharmacology Receptors, Adrenergic, beta / metabolism Solute Carrier Family 12, Member 1 / metabolism Solute Carrier Family 12, Member 3 / metabolism Kir5.1 Channel
hypertension ion transport isoproterenol norepinephrine propranolol

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
01 2019
Historique:
entrez: 21 12 2018
pubmed: 21 12 2018
medline: 14 11 2019
Statut: ppublish

Résumé

The stimulation of β-adrenergic receptor increases thiazide-sensitive NaCl cotransporter (NCC), an effect contributing to salt-sensitive hypertension by sympathetic stimulation. We now test whether the stimulation of β-adrenergic receptor-induced activation of NCC is achieved through activating basolateral Kir4.1 in the distal convoluted tubule (DCT). Application of norepinephrine increased the basolateral 40 pS K

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.118.11621 PMID: 30571558 PMC: PMC6319266
pubmed: 30571558
doi: 10.1161/HYPERTENSIONAHA.118.11621
pmc: PMC6319266
mid: NIHMS1509657
doi:

Substances chimiques

Adrenergic beta-Agonists 0
Adrenergic beta-Antagonists 0
Kcnj10 (channel) 0
Potassium Channels, Inwardly Rectifying 0
Receptors, Adrenergic, beta 0
Slc12a1 protein, mouse 0
Solute Carrier Family 12, Member 1 0
Solute Carrier Family 12, Member 3 0
Propranolol 9Y8NXQ24VQ
Isoproterenol L628TT009W
Norepinephrine X4W3ENH1CV

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

112-120

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK054983
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115366
Pays : United States

Références

JCI Insight. 2017 Sep 21;2(18):
pubmed: 28931751
J Am Soc Nephrol. 2017 Jan;28(1):209-217
pubmed: 27335120
Hypertension. 2013 Apr;61(4):806-11
pubmed: 23381790
Hypertension. 1980 May-Jun;2(3):266-73
pubmed: 6993358
Hum Mol Genet. 2011 Mar 1;20(5):855-66
pubmed: 21131289
Sci Signal. 2014 May 06;7(324):ra41
pubmed: 24803536
Biochim Biophys Acta. 2015 Nov;1852(11):2554-62
pubmed: 26319417
Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1277-87
pubmed: 23986512
J Biol Chem. 2014 Jun 20;289(25):17680-8
pubmed: 24811174
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11864-9
pubmed: 25071208
Hypertension. 2018 Apr;71(4):622-630
pubmed: 29483225
J Pharmacol Exp Ther. 1985 Feb;232(2):561-9
pubmed: 2982017
Kidney Int. 2018 Apr;93(4):893-902
pubmed: 29310825
J Biol Chem. 2013 Sep 6;288(36):26135-46
pubmed: 23873931
Hypertension. 2014 Jul;64(1):178-84
pubmed: 24799612
Biochem J. 2016 Oct 1;473(19):3237-52
pubmed: 27422782
Kidney Int. 2008 Dec;74(11):1403-9
pubmed: 18800028
Nat Med. 2011 May;17(5):573-80
pubmed: 21499270
J Am Soc Nephrol. 2017 Jun;28(6):1814-1825
pubmed: 28052988
Clin J Am Soc Nephrol. 2015 Jun 5;10(6):1050-60
pubmed: 24721891
EMBO J. 1996 Jun 17;15(12):2980-7
pubmed: 8670799
Am J Physiol Renal Physiol. 2008 Jun;294(6):F1398-407
pubmed: 18367659
J Physiol. 2002 Jan 15;538(Pt 2):391-404
pubmed: 11790808
J Am Soc Nephrol. 2015 Nov;26(11):2678-90
pubmed: 25848073
Kidney Int. 2006 Aug;70(4):630-4
pubmed: 16820787
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10361-6
pubmed: 21633011
Am J Physiol Renal Physiol. 2007 Mar;292(3):F1073-81
pubmed: 17122384
Cell Metab. 2011 Sep 7;14(3):352-64
pubmed: 21907141
Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1288-96
pubmed: 25834074
J Am Soc Nephrol. 2015 Aug;26(8):1781-6
pubmed: 25542968
Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F986-F996
pubmed: 29897283
Cell Metab. 2015 Jan 6;21(1):39-50
pubmed: 25565204
J Biol Chem. 2012 Nov 2;287(45):37673-90
pubmed: 22977235
Am J Physiol Renal Physiol. 2004 Dec;287(6):F1233-43
pubmed: 15280163
Am J Physiol Cell Physiol. 2015 May 15;308(10):C779-91
pubmed: 25788573

Auteurs

Xin-Peng Duan (XP)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).

Li Gu (L)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).

Yu Xiao (Y)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).

Zhong-Xiuzi Gao (ZX)

Department of Pharmacology, New York Medical College, Valhalla (Z.-X.G., P.W., D.-H.L., W.-H.W.).

Peng Wu (P)

Department of Pharmacology, New York Medical College, Valhalla (Z.-X.G., P.W., D.-H.L., W.-H.W.).

Yun-Hong Zhang (YH)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).

Xin-Xin Meng (XX)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).

Jun-Lin Wang (JL)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).

Dan-Dan Zhang (DD)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).

Dao-Hong Lin (DH)

Department of Pharmacology, New York Medical College, Valhalla (Z.-X.G., P.W., D.-H.L., W.-H.W.).

Wen-Hui Wang (WH)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).
Department of Pharmacology, New York Medical College, Valhalla (Z.-X.G., P.W., D.-H.L., W.-H.W.).

Ruimin Gu (R)

From the Department of Physiology, Harbin Medical University, China (X.-P.D., L.G., Y.X., Y.-H.Z., X.-X.M., J.-L.W., D.-D.Z., W.-H.W., R.G.).

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Agonistes adrénergiques › Agonistes bêta-adrénergiques › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Antagonistes adrénergiques › Antagonistes bêta-adrénergiques › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Eucaryotes › Animaux › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des ions › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Isoprénaline › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Tubules rénaux › Tubules contournés distaux › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Norépinéphrine › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Propranolol › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs adrénergiques › Récepteurs bêta-adrénergiques › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Symporteurs des ions sodium-potassium-chlorure › Membre-1 de la famille-12 des transporteurs de solutés › Norepinephrine-Induced Stimulation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Symporteurs des ions sodium-potassium-chlorure › Membre-3 de la famille-12 des transporteurs de solutés › Norepinephrine-Induced Stimulation of...